This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is funding the development of a single RT-qPCR reaction assay, the Zip-Melt DLBCL Classifier, to differentiate between Activated B-Cell (ABC) and Germinal Center B-Cell (GCB) subtypes of Diffuse Large B-Cell Lymphoma (DLBCL). The $607,916 award, effective May 1, 2024 through April 30, 2025, supports the optimization and performance evaluation of this 18-gene expression analysis multiplex assay. The goal is to provide a more efficient, cost-effective, and scalable solution for cancer gene expression profiling compared to current approaches requiring multiple qPCR reactions. This chemistry-based technology can be integrated into point-of-care systems to expand access in resource-limited settings. The awardee is Kasa Bio, LLC, a woman-owned small business.
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