The National Institute of General Medical Sciences (NIGMS) awarded a $290,986 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Chembind LLC on July 1, 2024. The project aims to synthesize 38 unique sulfated O-GalNAc glycans using a Sulfated Modular Synthesis/Enzymatic Assembly (SMSEA) approach. This comprehensive library of well-defined synthetic sulfated glycans will serve as an invaluable toolkit to advance the understanding of their biological functions in human health and diseases. The project also develops glycan microarray technology tailored to the multivalent presentation of these sulfated glycans, enabling the debut of the first-ever sulfated O-GalNAc glycan microarray. These research outputs are expected to significantly advance the field of functional glycomics.
Generated 1/28/25, 10:58 AM