Project Grant R43GM130228

This federal Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $277,380 to the University of Colorado-Denver to develop novel statistical methods for the powerful detection of weak microbiome-metabolome interactions with limited data. The key products and services to be delivered under this 1-year award include: Development of a powerful transfer-learning framework for high-dimensional regression models with...

The National Institute of General Medical Sciences (NIGMS) awarded a $591,530 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Smart Information Flow Technologies LLC (Sift) to develop "Gut Grief!", a web-based educational game that teaches high school students about the gut microbiome and its connection to human health. The Phase I project will produce a low-fidelity prototype that demonstrates game mechanics to teach core genomics concepts,...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research to study microbial biomarkers that can predict multi-drug resistant organism (MDRO) colonization and infection in solid organ transplant recipients. The $841,520 award to The Trustees of Columbia University in the City of New York will leverage whole-genome sequencing and metagenomic analysis of gut...

Biomesense Inc. received a $883,212 Project Grant award from the National Institutes of Health's National Center for Advancing Translational Sciences to develop a novel biosensor to accelerate investigations of the gut microbiome. The grant will support validating the microbial lysis and DNA isolation functions of a prototype biosensor over a 6-month period ending December 31, 2021. The biosensor is intended to enable dense, time-longitudinal sampling of participants' gut microbiomes in their...

This federal Project Grant award of $1,255,725.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) aims to advance defined live biotherapeutic products (LBPs) for the treatment of recurrent Clostridioides difficile infection (rCDI) and ulcerative colitis. The key objectives are to: 1) Develop a solid-state fermentation platform to increase the scale and throughput of...

This $976,771 Cooperative Agreement awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program will support Biomesense Inc., a for-profit biotechnology company, in the development of a novel measurement platform to enable large-scale, longitudinal studies of the gut microbiome. The key products to be delivered through this project include: (1) refinement of processes for capturing and storing microbial RNA from gut samples, (2)...

The National Science Foundation's Division of Integrative Organismal Systems awarded a $1,012,111 Project Grant to The Ohio State University to conduct research using machine learning and animal models to identify bacterial species and sub-networks within complex gut microbiomes that are essential for healthy animal development and growth. This interdisciplinary project leverages molecular and microbiological approaches, as well as legacy and cutting-edge machine learning tools, to analyze...

This $325,139 federal Project Grant award, funded by the National Center for Advancing Translational Sciences (NCATS), 93.350 program, aims to examine the feasibility of using target-specific polyclonal antibodies to neutralize bioactive molecules in the gut microbiome. The primary goals are to 1) determine the impact of six proteins identified as overabundant in inflammatory gut disorders, and 2) evaluate the ability of immunoglobulin Y (IgY) antibodies to neutralize the physiological impacts...

This $202,728 federal Project Grant awarded by the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program funds a collaborative research project to develop a theragnostic (therapeutic and diagnostic) system for inflammatory bowel diseases (IBD). The project aims to integrate data science, synthetic biology, and additive manufacturing to model the complex interplay of host, microbial, and environmental factors in IBD, and develop an engineered...

This federal Project Grant award of $854,736, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop a comprehensive suite of statistical tools for analyzing longitudinal microbiome studies. The key products and services to be delivered include: Methods for addressing batch effects in longitudinal microbiome data, which is a critical issue as studies grow larger or integrated. Improved...