Project Grant R43GM125462

This $999,996 Project Grant award, provided by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074), supports fundamental research aimed at generating "designer mitochondria" for biotechnology, healthcare, and basic research applications. The key objectives are to identify the factors required for human mitochondrial DNA (mtDNA) replication and characterize the mechanisms underlying the species-specificity of this process. This work represents a critical step...

This $1,000,000 four-year Project Grant from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will fund research at Northeastern University exploring the role of mitochondria in regulating cell fate decisions during early mammalian development. Specifically, the researchers will test the hypothesis that differential allocation of mitochondrial subtypes, which vary in biochemical properties and protein content including levels of the transcription factor TEAD4,...

This Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) provides $150,000.00 to the University of South Alabama to enhance the natural repair mechanisms of mitochondrial DNA (mtDNA). The project aims to improve the targeting of key DNA repair enzymes to mitochondria, which are essential cellular organelles, without disrupting their other cellular functions. By using a novel computational framework to optimize mitochondrial targeting...

Federal Grant Award Summary The National Human Genome Research Institute (NHGRI) awarded Massachusetts Institute of Technology a $266,664 Project Grant effective August 18, 2025, under the Human Genome Research program (CFDA 93.172) to develop measurement systems and methodologies for quantifying translation initiation kinetics across the human genome. Over the five-year project period through July 31, 2027, MIT will adapt its MIT-SEQ functional genomics platform—originally developed for...

This $1,373,044 project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at the Massachusetts Institute of Technology to develop microbial strains with minimal genomes for integrated bioprocessing using supercritical carbon dioxide. The goal is to elucidate the genotype-phenotype relationship of tolerance to supercritical CO2 for a selected microorganism and construct a reduced genome strain displaying the desired tolerance phenotype....

Federal Grant Award Summary Harvard College's Office for Sponsored Programs received a $773,479 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, through May 31, 2029. The award supports the development and application of mitochondrial gene editing technologies in human cardiomyocytes to advance understanding of mitochondrial DNA (mtDNA) mutations and their role in cardiomyopathy....

This three-year, five-hundred twenty-three thousand four-hundred sixty-one dollar project grant from the National Science Foundation's Division of Molecular and Cellular Biosciences will fund research into RNA processing in trypanosome mitochondria. The grant was awarded to Seattle Children's Research Institute on April 1, 2022 and will be completed by March 31, 2025. The project aims to advance understanding of gene expression regulation in trypanosomes, single-celled parasites that alternate...

This Project Grant award from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) provides $400,000 to the Massachusetts Institute of Technology (MIT) to develop the ENZYME research ecosystem. The goal is to enable the automatic generation of derivatives for arbitrary programs written in LLVM-based languages, making it easier for scientists and engineers to apply modern algorithms like machine learning to their domains without...

This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $280,000 over 3 years to Auburn University to investigate the roles of mitochondrial behavior and morphology in animal performance. The key objectives are to test the hypotheses that: 1) changes in mitochondrial shape and movement increase ATP production, and 2) mitochondrial characteristics play critical roles in how animals respond to factors like food availability,...

This Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) provides $452,375 to The Trustees of Columbia University in the City of New York to develop a platform for rapid and efficient generation of multi-site sequence variants using template-guided gene synthesis. The project aims to advance this synthesis approach by optimizing predictive algorithms, experimental protocols, and robotic automation to produce kilobase-sized DNA constructs up...