This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, provides $574,042 to Vivoverse, LLC, a woman-owned small business in Austin, Texas, to develop high-content in vivo developmental neurotoxicity (DNT) testing using the C. elegans model organism. The project aims to establish a comprehensive DNT test battery that tracks neuronal, synaptic, and behavioral changes in C. elegans exposed to DNT toxicants...
This $1,847,940 federal Project Grant awarded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program supports research to accelerate the development, adoption, and refinement of data and metadata standards for studying emerging water contaminants and their impacts on human health. The key objectives are to: 1) create rich machine-readable metadata and minimum information standards for environmental exposure assessment, 2) annotate,...
The National Institute of Environmental Health Sciences (NIEHS) awarded a $2,247,563 Project Grant under the Environmental Health (CFDA 93.113) federal grant program to Research Triangle Institute (RTI International), a non-profit research organization in North Carolina. The grant will fund the development of improved data standards and semantic descriptions to enhance integration and interoperability across the "source to outcome" (S2O) continuum in environmental health science....
The National Institutes of Health National Institute of Environmental Health Sciences awarded a $924,612 Project Grant to the California State University, East Bay Foundation, Inc. under the Environmental Health (CFDA 93.113) federal grant program. The grant will fund research from August 2022 to July 2025 to advance chemical risk assessment and predictive toxicology through the development, validation and integration of high-throughput mechanistic in vitro assays. Specifically, the grantee will...
The National Institute of Environmental Health Sciences (NIEHS) awarded this $558,380 Project Grant under the Environmental Health (CFDA 93.113) Federal Grant Program. The grant funds the development of an integrated biomedical knowledgebase and geospatial data science ecosystem called the "Geospatial Knowledgebase for Exposomics (GEOSPACE)". The project aims to create a curated database of high-confidence environmental exposure data and link it to biological pathways and health...
The National Institute of Environmental Health Sciences (NIEHS) awarded a $553,708 five-year Project Grant under the Environmental Health (CFDA 93.113) program to the University of North Carolina at Chapel Hill (UNC-CH). The grant funds the development of community-driven standards and a visual atlas for annotating and integrating zebrafish toxicological data and phenotypes. Key products and services to be delivered include: 1) creating a standardized toxicology data model and ontology to enable...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) Federal Grant Program, is funding a $184,572 research project titled "From the Cell to the Street: Personalized Report-Back in Large Cohort Studies with Multi-Level Measurements." The key products and services being delivered through this grant include: Developing innovative participant-centered methods for personalized report-back of multi-level...
This $615,941 federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113) supports the development of a community-driven, standards-based informatics infrastructure to enable robust metadata management and data integration for environmental exposure health research. The key products and services to be delivered include: Developing a logical model to represent diverse sensor metadata and harmonize...
This $304,971 Project Grant awarded by the National Institute of Environmental Health Sciences (NIEHS) under the Medical Library Assistance (CFDA 93.879) program supports the development of an AI-based tool to automate the extraction of data from tables in published medical studies. The goal is to integrate this tabular extraction capability into Nested Knowledge's existing software platform for conducting systematic literature reviews (SLRs). This would help address a key bottleneck in the...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) federal grant program provides $2,434,186 to Vala Sciences Inc., a for-profit research company based in San Diego, California. The award will fund the development of a suite of in vitro assays, called the DevNeurotoXAssay (DNTA) suite, to test chemicals and toxicants for potential developmental neurotoxic effects. The DNTA assays will utilize human induced...
This $249,943 Project Grant award from the National Institutes of Health's National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program supports the research and development of an adverse outcome pathway-focused mechanistic inference tool for 'omics data using semantic knowledge graphs.
The key products and services to be delivered through this one-year award include:
Improving statistical models to better quantify adverse outcome pathway enrichment from experimental data
Enhancing natural language processing to map arbitrary adverse outcome pathway event descriptions to a controlled biomedical knowledge graph vocabulary
Developing a web-based interactive visualization tool to explore enriched relationships across time points, generating mechanistic hypotheses in an intuitive framework.
The overarching goal is to provide an easy-to-use, data-driven tool that leverages adverse outcome pathways to support regulatory decision-making and the development of non-animal testing strategies for environmental health research.