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All Federal Grant Awards
Project Grant R43ES029406
Award Date
7/1/18
Completion Date
6/30/20
Dollars Obligated
$225K
Overview
Activity
4
Transactions
4
Subawards
Similar Awards
Federal Agency
National Institute of Environmental Health Sciences
Awardee
Predictive Biology, Inc. (F1PNSXJZC269)
Federal Grant Program
93.113
Assistance Type
Project Grant
Place of Performance
Carlsbad, CA 92010, USA
Update #1
Update #2
SINGLE CELL ANEUGEN ASSAY IN NEURAL PROGENITOR CELLS
Posted 6/19/18
5
1
Mod #
Description
ReasonForModification
Federal Obligation
Date
Not listed
SINGLE CELL ANEUGEN ASSAY IN NEURAL PROGENITOR CELLS - ABSTRACT: ANEUPLOIDY IS A COMMON FEATURE OF MANY CONGENITAL DISORDERS SUCH AS DOWN'S SYNDROME, OR TRISOMY21. IT IS AN EXTREMELY COMMON FEATURE IN CANCER, AND NEARLY ALL SOLID TUMORS AND ALMOST HALF OF HEMATOPOETIC CANCERS ARE ANEUPLOID. THE CURRENT GOLD STANDARD FOR ASSESSMENT OF ANEUGEN ACTIVITY IS THE MICRONUCLEUS ASSAY. WE ARE DEVELOPING A NOVEL MOLECULAR ASSAY FOR ANEUPLOIDY USING SINGLE CELL RNA SEQUENCING (SCRNASEQ). THE ASSAY WILL INDICATE WHETHER A CELL IS EUPLOID OR ANEUPLOID, WHICH CHROMOSOME(S) AFFECTED, AND HOW A TOXICANT HAS AFFECTED THE TARGET CELL TRANSCRIPTOME, EITHER INDEPENDENT OF OR IN CONJUNCTION WITH ONE OR MORE ANEUPLOID CHROMOSOMES. ELUCIDATION OF THE AFFECTED OR PREDICTIVE PATHWAYS, GENE FAMILIES AND CELLULAR PROCESSES WILL PROVIDE A RICH, HIGHLY DETAILED GLOBAL VIEW OF THE CONSEQUENCES OF COMPOUND EXPOSURE ON A CELL, AND MAY LEAD TO A MOLECULAR UNDERSTANDING OF DIFFERENT FATES FOR DIFFERENT CHROMOSOME ANEUPLOIDIES.
$0
1/30/21
Not listed
SINGLE CELL ANEUGEN ASSAY IN NEURAL PROGENITOR CELLS - ABSTRACT: ANEUPLOIDY IS A COMMON FEATURE OF MANY CONGENITAL DISORDERS SUCH AS DOWN'S SYNDROME, OR TRISOMY21. IT IS AN EXTREMELY COMMON FEATURE IN CANCER, AND NEARLY ALL SOLID TUMORS AND ALMOST HALF OF HEMATOPOETIC CANCERS ARE ANEUPLOID. THE CURRENT GOLD STANDARD FOR ASSESSMENT OF ANEUGEN ACTIVITY IS THE MICRONUCLEUS ASSAY. WE ARE DEVELOPING A NOVEL MOLECULAR ASSAY FOR ANEUPLOIDY USING SINGLE CELL RNA SEQUENCING (SCRNASEQ). THE ASSAY WILL INDICATE WHETHER A CELL IS EUPLOID OR ANEUPLOID, WHICH CHROMOSOME(S) AFFECTED, AND HOW A TOXICANT HAS AFFECTED THE TARGET CELL TRANSCRIPTOME, EITHER INDEPENDENT OF OR IN CONJUNCTION WITH ONE OR MORE ANEUPLOID CHROMOSOMES. ELUCIDATION OF THE AFFECTED OR PREDICTIVE PATHWAYS, GENE FAMILIES AND CELLULAR PROCESSES WILL PROVIDE A RICH, HIGHLY DETAILED GLOBAL VIEW OF THE CONSEQUENCES OF COMPOUND EXPOSURE ON A CELL, AND MAY LEAD TO A MOLECULAR UNDERSTANDING OF DIFFERENT FATES FOR DIFFERENT CHROMOSOME ANEUPLOIDIES.
$0
1/30/21
Not listed
SINGLE CELL ANEUGEN ASSAY IN NEURAL PROGENITOR CELLS
$0
8/7/19
Not listed
SINGLE CELL ANEUGEN ASSAY IN NEURAL PROGENITOR CELLS
$224.8k
6/19/18