Project Grant R43CA295295
- The federal Project Grant award of $186,250.00 was provided by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to the University of Virginia to develop and characterize membrane-sensitive fluorescent probes for measuring local membrane environments of membrane proteins in living cells. The key objectives are to: 1) calibrate various fluorescent sensors to specific membrane structural parameters and determine their spatial sensing range, and 2) demonstrate proof-of-concept...
- This Project Grant from the National Institutes of Health's National Cancer Institute totaling $668,151 will support the development of highly multiplexed live-cell G protein-coupled receptor (GPCR) arrays for glioma drug discovery. Spectragenetics, Inc. will deploy an automated multiplexed live-cell assay to detect and quantify agonist and inverse-agonist activities against 55 GPCRs known to be upregulated or downregulated in human gliomas. The assay will be used to screen 48 established...
- This $415,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports fundamental research on the structure and function of G protein-coupled receptors (GPCRs). The research aims to bridge gaps in understanding the complexity of GPCR signaling pathways and their promiscuous activation of diverse G protein subfamilies. The five-year project, awarded to Sanford Research, a nonprofit...
- This Project Grant award for $450,904 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) will support the development of a single-cell (phospho-)proteomics platform at the Pacific Northwest National Laboratory, operated by Battelle Memorial Institute. The platform aims to address key challenges in single-cell proteomics analysis, including low recovery for phospho-enrichment, insufficient mass spectrometry sensitivity, and low sample throughput. This new platform will...
- This federal Project Grant award of $418,176 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports the development and validation of a novel approach called "Programmable Nucleic Acid Cytometry" at the Sloan-Kettering Institute for Cancer Research. The project aims to advance this innovative method for profiling rare cell populations from tumors and tissues, which offers advantages over traditional antibody-based cell isolation techniques. The work will...
- This $576,493.00 federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) aims to develop sophisticated, self-calibrating near-infrared fluorescent probes that can quantitatively assess microviscosity variations and monitor protein misfolding/aggregation within live cells. The probes are designed to have enhanced water solubility, stability, and cell permeability to maximize biocompatibility and selectivity for detecting viscosity changes and protein...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $144,961 to Central Michigan University to develop a bioluminescent sensor for focal adhesion kinase (FAK) and conduct a genome-wide CRISPR knockout screen to identify regulators of cellular adhesion. The research aims to provide real-time insights into FAK activity within living cells and uncover novel genes that regulate...
- This federal Project Grant award from the National Cancer Institute (NCI) under CFDA 93.396 (Cancer Biology Research) provides $182,755 to Cold Spring Harbor Laboratory (CSHL) to conduct research on genetic technology development for understanding lineage plasticity mechanisms in cancer. The award began on August 21, 2025 and is scheduled for completion on July 31, 2030. The key products and services to be delivered through this grant include: 1) developing a CRISPR screening methodology for...
- The National Institute of General Medical Sciences (NIGMS) awarded a $366,250 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Central Michigan University. The grant, which runs from January 1, 2025 to December 31, 2029, aims to develop bioluminescent kinase sensors to monitor and manipulate cell signaling processes related to cell growth, division, and the cell cycle. The proposed research seeks to create novel tools for studying cell biology and...
- This federal Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the development and validation of an innovative assay for measuring and targeting the drug target sphingosine kinase (SphK) in cancer cells. Piccolo Biosystems, Inc., an early-stage biotechnology company, will collaborate with scientists at the University of Washington to leverage their patent-pending...
This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides funding of $364,367 to Montana Molecular LLC to develop fluorescent biosensors for measuring the signaling kinetics of G-protein coupled receptor (GPCR) ligands that activate the G12/13 signaling pathways. The goal is to create a live-cell, fluorescent assay that can be used on standard plate readers to provide kinetic data on G12/13 pathway activation in response to different compounds, across various cell types including cancer cell lines. The award also aims to develop CRISPR/Cas9 tools with guide RNAs to selectively knock out different G proteins, in order to study crosstalk between G-protein signaling pathways. This research is intended to advance the understanding of GPCR-mediated cancer biology and support the development of new therapeutic interventions targeting the G12/13 signaling axis. The project will be conducted over a 1-year period from September 1, 2025 to August 31, 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $364.4k | 8/25/25 |