Project Grant R43AR077462

Federal Cooperative Agreement Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the Regents of the University of Michigan a $2.85 million Cooperative Agreement (CFDA 93.279, Drug Use and Addiction Research Programs) effective September 19, 2025, through July 31, 2030, to conduct a Sequential Multiple Assignment Randomized Trial (SMART) study addressing personalized treatment approaches for chronic low back pain (CLBP). The research addresses a critical...

Federal Cooperative Agreement Summary The National Institute of Neurological Disorders and Stroke awarded a $1.365M Cooperative Agreement to Massachusetts General Hospital under the Drug Use and Addiction Research Programs (CFDA 93.279) for the project "Continuous Monitoring of Pain Using Facial Expressions in ICU Environment" (COMPANION). Awarded on August 1, 2025, with a completion date of July 31, 2027, this phased initiative develops AutoBPS, a facial-expression-based machine...

This Cooperative Agreement award from the U.S. Food and Drug Administration (FDA), under the FDA Research program (CFDA 93.103), provides $1,999,980 to Oregon Health & Science University (OHSU) to develop evidence-based clinical practice guidelines for the management of acute low back pain. The project aims to conduct a systematic review of the literature, derive clinical guidelines, and implement a dissemination and evaluation campaign to drive adoption of the guidelines. OHSU has...

Award Summary The National Institute of Neurological Disorders and Stroke awarded Trustees of Boston University a Cooperative Agreement valued at $1.61M (obligated August 1, 2025 through July 31, 2027) under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop a novel composite digital endpoint integrating synchronized measures of pain and gait patterns for knee osteoarthritis assessment. The project will deliver validated digital measurement tools designed to provide more...

Summary Duke University received a $1.98M Cooperative Agreement award dated April 23, 2026, from the National Center for Complementary and Integrative Health (NCCIH) under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The award funds a four-site, multicenter randomized controlled trial (RCT) evaluating the efficacy of LIFT, a self-directed mobile mindfulness intervention designed to address psychological distress in survivors of cardiorespiratory...

Federal Cooperative Agreement Summary: Equitable Primary Care for Pain Care (EquiP PC) The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Washington a $1,024,374 Cooperative Agreement on August 11, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and test implementation strategies for integrating behavioral health into primary care for chronic pain management. The project, titled Equitable Primary Care for Pain Care...

Grant Award Summary The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded $637,554 under its Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop AudioSight, a smartphone-based diagnostic system for objective assessment of sound sensitivity and tolerance (SST) disorders. The project, managed by The Research Foundation for the State University of New York and performed at the University at Buffalo (Buffalo,...

This Project Grant award, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to develop computational tools to accurately predict and interpret different patterns of knee pain in patients with osteoarthritis. The $348,680 award, with a period of performance from Sep 26, 2024 to Aug 31, 2026, will enable researchers at the University of Arizona to: 1) Adapt a...

Summary Wayne State University received a $385,517 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) awarded August 15, 2025, with completion targeted for July 31, 2027. The project focuses on validating a novel wearable device called TRACE that measures orthostatic vital signs through an earlobe-based platform. The research aims to validate TRACE's four orthostatic metrics against transcranial Doppler (TCD) ultrasound—the gold standard for...

The University of North Carolina at Chapel Hill received a $100,000 Project Grant award from the National Science Foundation under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop a digital therapeutic device and mobile application for patients with high-tone pelvic floor disorders. The award will support the creation of an interactive pelvic wand and accompanying smartphone app to enable patients to conduct targeted pelvic floor muscle physical therapy...