Project Grant R41TR005541
- This Project Grant award from the National Center for Advancing Translational Sciences (NCATS), under CFDA Program 93.350, provides $329,272 to Capienda Biotech, LLC to develop a high-throughput kinetic system for small-molecule drug discovery. The goal is to create an innovative instrument that can rapidly characterize the binding kinetics of compounds targeting human cyclin-dependent kinases, which are important oncology targets. This will help medicinal chemists identify drug candidates...
- The National Center for Advancing Translational Sciences (NCATS), under CFDA 93.350, has awarded a $324,962 Project Grant to Tetmedical, Inc. to develop a technology for rapid, point-of-care and at-home testing of liver enzyme levels. The goal is to enable convenient and timely monitoring of drug-induced liver injury (DILI) and other sources of liver damage. The project aims to optimize tethered enzyme assays for detecting aspartate aminotransferase (AST) and alanine aminotransferase (ALT),...
- The National Center for Advancing Translational Sciences (NCATS), under the CFDA Program 93.350, awarded a $338,997 Project Grant to Mabswitch Inc. effective January 1, 2024 to December 31, 2024. The project aims to develop "LENTISAFE LIGANDS: MILD-ELUTION IMMUNOAFFINITY LIGANDS FOR ENRICHMENT AND PURIFICATION OF LENTIVIRAL VECTORS." The goal is to create switchable affinity ligands that can be used to selectively isolate and enrich functional lentiviral vectors from production...
- This $305,352 Project Grant awarded by the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) supports the development of a quantitative, home monitoring point-of-care test for determining total blood homocysteine (THCY) levels. The funding will allow Analytical Diagnostic Solutions Inc., a for-profit S corporation based in New Jersey, to create the "HCY NOW" device, which aims to significantly improve the management of homocystinurias (HCUs) - a group of...
- The National Center for Advancing Translational Sciences (NCATS) awarded a $275,000 Project Grant (CFDA 93.350) to Nectagen Inc. to develop bioprocess-compatible, second-generation nanoclamp affinity resins for the efficient purification of plasma-based therapeutic proteins. The goal is to identify panels of nanoclamps to 5 industrially relevant plasma-based therapeutics, select lead candidates, and optimize the resins for maximum recovery and purity from plasma samples. This project aims to...
- The National Center for Advancing Translational Sciences (NCATS) awarded a $1,050,276 Project Grant to Syntr Health Technologies, Inc. on September 25, 2025 under the CFDA 93.350 Federal Grant Program. This funding supports the development and automation of an FDA-cleared CD-microfluidic platform for rapid tissue microsizing. The platform technology can process a variety of tissue types, including cancer tumors and adipose tissue, to enable single-cell analysis and regenerative medical...
- This federal Project Grant award of $348,848 was provided by the National Center for Advancing Translational Sciences (NCATS) under the CFDA program 93.350 - National Center for Advancing Translational Sciences. The grant aims to diversify the cyclization positions in mRNA display libraries, a method of rapidly generating large protein-peptide binding datasets and discovering novel peptide therapeutics. The funded work will leverage a new approach called Segmented In Vitro Translation (SIVT)...
- This $412,632 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to advance the biocatalytic synthesis of complex medicinal small molecules. The award, with a performance period from August 1, 2025 to July 31, 2030, will fund the development of computer-aided synthesis planning (CASP) tools to generalize known enzymatic reactions and predict routes for producing...
- This Project Grant award from the National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health, is providing $349,952 to Intero Biosystems Inc. to develop a novel human intestinal organoid screening platform. The goal is to create a more physiologically-relevant in vitro model that can accurately mimic human intestinal tissue for preclinical drug testing, with the potential to reduce high failure rates in clinical trials. The 1-year project will first...
- This R03 project grant, awarded by the National Center for Advancing Translational Sciences (NCATS) under CFDA Program 93.350, aims to comprehensively identify metabolic enzymes that control the generation of TCF1+ progenitor CD8+ T cells, which are critical for durable anti-tumor immune responses. The $169,500 award, spanning from September 1, 2024 to August 31, 2026, will fund two key research objectives: Identifying metabolic enzymes whose loss alters T cell differentiation and the TCF1+...
This National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS) Project Grant award of $285,444, effective August 15, 2025 through August 14, 2026 (CFDA 93.350), aims to develop recombinant human enzyme panels representing genetic variants of drug-metabolizing enzymes present in the U.S. patient population. The goal is to bridge shortcomings in current in vitro drug metabolism testing, which typically relies on liver microsomes or hepatocytes from genetically similar donors, limiting applicability to diverse patient groups. The project will leverage recombinant proteins to generate commercially viable kits representing polymorphic drug-metabolizing enzymes, such as cytochrome P450s, N-acetyltransferases, and thiopurine S-methyltransferase, to enable more comprehensive in vitro testing during drug development and support personalized medicine approaches.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $285.4k | 8/13/25 |