Project Grant R41HL151025

Endoshape, Inc. was awarded a $370,938 project grant from the National Heart, Lung, and Blood Institute of the National Institutes of Health to develop radiopaque shape memory polymers for neurovascular embolotherapy applications. The Cardiovascular Diseases Research program aims to support heart and vascular research, including through competitive research training grants. Under this award, Endoshape will develop new radiopaque shape memory polymer materials incorporated into embolic coils....

This $786,188 Project Grant awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports the development of a novel biodegradable hydrogel-based gene therapy delivery system to prevent prosthetic bypass graft failure. The research team at Beth Israel Deaconess Medical Center, Inc. (Bidmc) aims to optimize the hydrogel platform's efficiency and efficacy, including increasing degradation length and arterial tissue...

This federal Project Grant award of $706,616 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports the development of a fully biodegradable, elastic, and conductive cardiac patch combined with cardiac stromal cell-derived exosomes to promote heart function restoration after myocardial infarction. The key products or services to be delivered through this award include: 1) optimizing and characterizing a biodegradable...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $298,371 to Anova Biomedical, Inc. to develop a new class of biodegradable and elastic vascular grafts for hemodialysis access. The proposed grafts are designed to address the shortcomings of current expanded polytetrafluoroethylene (ePTFE) arteriovenous grafts, which often fail due to...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $304,906 to Seabird Lifesciences LLC supports the development of an innovative bioprinting approach for creating vascular grafts that closely mimic the properties of natural blood vessels. The project aims to overcome limitations of current synthetic and biological grafts by utilizing a specialized bioprinting process that integrates a double-network hydrogel made from a Dacron...

The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $350,000 Project Grant to Karios Technologies LLC to develop TissueShield, a novel single-use, ready-to-use, sterile, dual-chamber, dual-syringe sprayable hydrogel for preventing post-surgical cardiac adhesions. TissueShield is a 3-component polymer system that can be easily sprayed directly onto the heart, forming a robust anti-adhesion layer within seconds. The...

This Project Grant award of $738,356 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research Program (CFDA 93.837) supports the preclinical optimization and design for manufacturability of immunoregulatory tissue-engineered vascular grafts (TEVGs). The funded research aims to evaluate a specific TEVG configuration consisting of a silk scaffold seeded with extracellular vesicles to validate the construct's performance in vitro and in a large animal...

The National Heart, Lung, and Blood Institute (NHLBI) awarded a $311,824 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Nytricx, Inc. to develop an endovascular prosthetic graft device that integrates nitric oxide (NO)-releasing polymer technology. The goal is to create a medical device that can reduce the incidence of infection, neointimal proliferation, and thrombosis - three major complications affecting patients following endovascular arterial repair...

This Project Grant from the National Institutes of Health's National Institute of Biomedical Imaging and Bioengineering will fund research at Hofstra University related to the development of plant-based vascular grafts. With $790,800 in funding over three years from August 2022 to July 2025, the university will pursue tissue engineering techniques to decellularize plant leaves and condition them as scaffolds for vascular grafts. The research aims to create a nonthrombogenic graft that mimics the...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) federal grant program provides $595,464 to Cerulean Scientific Inc. to develop and optimize a tethered liquid perfluorocarbon (TLP) coating for peripheral vascular grafts. The TLP coating aims to prevent thrombosis, biofilm formation, and other complications that often lead to failure of these medical devices. Over the 18-month project period ending March...