Project Grant R41HG014741
- The National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), awarded Evizia Inc. a $1,234,692 project grant on April 7, 2025. The grant supports the development of a novel biomolecule desktop imaging system called PRECYSE, which uses high-speed atomic force microscopy (HSAFM) to provide improved quality control for next-generation sequencing (NGS) sample preparation. The PRECYSE system can rapidly size DNA samples from 100 base...
- The National Human Genome Research Institute (NHGRI), under the Federal Grant Program for Human Genome Research (CFDA 93.172), awarded a $397,599 Project Grant to Xgenomes Corp. in Cambridge, MA. The grant supports the development of a novel epigenetic analysis method that can directly detect DNA methylation patterns across the genome with high accuracy, overcoming limitations of current sequencing techniques. The project aims to create advanced molecular analysis platforms that leverage machine...
- The National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), awarded a $384,418 Project Grant to Xgenomes Corp. on September 25, 2024 to develop a revolutionary DNA sequencing platform. The project aims to create a super-resolution single-molecule sequencing technology that can read short sequence "words" rather than individual nucleotides, enabling one or more orders of magnitude improvements in accuracy and cost over...
- The National Human Genome Research Institute (NHGRI) awarded a $1,711,422 Project Grant (CFDA 93.172 - Human Genome Research) to the New York Genome Center, Inc. (NYGC) on September 23, 2024. The goal of this project is to develop a suite of privacy-preserving tools for transcriptomic data analysis, including methods for quantifying bulk and single-cell gene expression, as well as performing expression quantitative trait locus (eQTL) mapping on encrypted genotypes. This will enable large-scale...
- The National Human Genome Research Institute (NHGRI) awarded a $291,232 Project Grant to Micropure Genomics Inc. on September 17, 2025 under the Human Genome Research Federal Grant Program (CFDA 93.172). The project aims to develop an automated, bead-less, and gel-less microfluidic size selection approach to simplify workflows, reduce costs, and enhance the performance of long-read DNA sequencing technologies such as PacBio and Oxford Nanopore. The proposed innovation, called mPREP, leverages...
- The National Human Genome Research Institute (NHGRI), under the Human Genome Research CFDA 93.172 federal grant program, awarded a $1,020,280 Project Grant to Vellum Biotechnology, Inc. to develop a new nucleic acid extraction technology to enable high-quality DNA sequencing for formalin-fixed paraffin-embedded tissue (FFPET) samples. This project aims to address challenges in obtaining consistent quality and yield of purified nucleic acids from FFPET samples, which are widely used in diagnostic...
- The National Human Genome Research Institute (NHGRI), under the Human Genome Research federal grant program (CFDA 93.172), awarded a $383,748 project grant to Jumpcode Genomics Inc. The grant supports the development of a CRISPR-based depletion technology to resolve pseudogene contamination in next-generation sequencing (NGS)-based genetic testing, with a focus on improving newborn screening (NBS) clinical tests. The goal is to enhance the sensitivity and specificity of detecting disease-causing...
- The National Human Genome Research Institute (NHGRI) awarded a $470,637 Project Grant on April 4, 2025 to President and Fellows of Harvard College, doing business as Harvard Medical School, for the "SELF-EVOLVR: SELF-REFRESHING MOLECULAR BARCODES USING CRISPR-SELF-GUIDED MUTAGENESIS" project. The project aims to develop a new self-refreshing DNA barcode technology called "SELF-EVOLVR" to enable high-resolution lineage tracing across various biological systems. The research...
- The National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), awarded a $1,341,011 Project Grant to the University of Pittsburgh to develop a novel computational framework that leverages deep learning and causal discovery algorithms. The goal is to uncover individualized cell-cell communication networks underlying the heterogeneity of tissue environments. This framework aims to model causal relationships between cellular states and...
- This $178,416 Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) supports research by the Whitehead Institute for Biomedical Research to explore the concept of "transcriptional adaptation" - a novel mechanism by which cells can compensate for certain genetic mutations. Key objectives include characterizing the molecular properties of "trigger RNAs" that can induce transcriptional adaptation, as well as investigating how...
The National Human Genome Research Institute (NHGRI), under the Human Genome Research federal grant program (CFDA 93.172), awarded a $396,170 project grant to Syntaxisbio Inc. on September 17, 2025. The grant supports the development of an innovative technology using genetic PUFs (Physical Unclonable Functions) to precisely quantify the age and division/passage history of cell lines. This technology aims to address the critical challenge of reliable cell line identification and validation in biomedical research. By embedding unique, robust, and unclonable genetic identifiers within cell lines, the project will enable accurate tracking of cell line provenance and age. This is expected to enhance the reproducibility and reliability of experimental outcomes in the biomedical field, where there is currently no commercially available method to reliably calculate and attest cellular age. The project will run through August 31, 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $396.2k | 9/17/25 |