Project Grant R41HG014454
- The National Human Genome Research Institute (NHGRI) awarded a $1,375,594 Project Grant under the Human Genome Research program (CFDA 93.172) to The Broad Institute, Inc. The grant, with a performance period from January 8, 2025 to December 31, 2028, will fund the development of a novel platform called Helicase-Assisted Continuous Evolution (HACE) for performing multiplexed locus-specific hypermutation within the mammalian genome. This technology aims to systematically evolve entire gene...
- This Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research program (CFDA 93.172), provides $446,042 to The Children's Hospital Corporation (dba Boston Children's Hospital) to develop and evaluate a web-based application called NEST. NEST is designed to empower families of infants diagnosed with rare genetic conditions to obtain appropriate follow-up care and management through personalized healthcare plans. The key objectives are to: 1)...
- The National Human Genome Research Institute (NHGRI) awarded a $1,711,422 Project Grant (CFDA 93.172 - Human Genome Research) to the New York Genome Center, Inc. (NYGC) on September 23, 2024. The goal of this project is to develop a suite of privacy-preserving tools for transcriptomic data analysis, including methods for quantifying bulk and single-cell gene expression, as well as performing expression quantitative trait locus (eQTL) mapping on encrypted genotypes. This will enable large-scale...
- The National Human Genome Research Institute (NHGRI) awarded a $579,698 Project Grant (CFDA 93.172 - Human Genome Research) to the Fred Hutchinson Cancer Center in Seattle, Washington to develop the "FACETING GEMS (Genomic Education Modules) for the Entry-Level Workforce" program. The program aims to address the gap in genomics education at under-resourced community colleges by: 1) Providing accessible, research-focused genomics training modules; 2) Training and motivating partner site...
- The National Human Genome Research Institute (NHGRI), under the Human Genome Research federal grant program (CFDA 93.172), awarded a $158,509 project grant to Rockefeller University. The grant, awarded on February 1, 2025, supports the establishment of a novel model for studying germline selection mechanisms using the germline restricted chromosome (GRC) in songbirds. The project aims to derive a high-quality GRC assembly through long-read sequencing, identify sequence differences between the...
- This federal Project Grant award of $196,296 was provided by the National Human Genome Research Institute (NHGRI) under the Human Genome Research federal grant program (CFDA 93.172). The award will support research to understand the relationship between genetic relatedness and phenotypic covariance, with a focus on investigating potential biases in heritability estimates due to factors like incomplete linkage disequilibrium and long-range haplotype sharing. The research will also develop...
- This $400,000 Project Grant award from the National Human Genome Research Institute (NHGRI) under CFDA 93.172 "Human Genome Research" will support a research program at Brigham & Women's Hospital to develop advanced computational methods for accurately identifying and genotyping structural variants within large genetic biobank datasets. The key objectives of the work are to: 1) create haplotype-informed algorithms to improve detection sensitivity and genotyping accuracy for...
- The National Human Genome Research Institute (NHGRI) awarded a $470,250 Project Grant (CFDA 93.172 - Human Genome Research) to Children's Hospital Los Angeles (CHLA) to explore the perspectives of diverse parents on issues related to pediatric genome testing, research, and data management. The award will fund a qualitative pilot study utilizing focus groups, interviews, and a survey to: (1) examine attitudes towards genome sequencing for clinical testing and research with a focus on...
- The National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), awarded a $384,418 Project Grant to Xgenomes Corp. on September 25, 2024 to develop a revolutionary DNA sequencing platform. The project aims to create a super-resolution single-molecule sequencing technology that can read short sequence "words" rather than individual nucleotides, enabling one or more orders of magnitude improvements in accuracy and cost over...
- The National Human Genome Research Institute (NHGRI), under CFDA 93.172 - Human Genome Research, awarded a $550,810 Project Grant to the University of California, Irvine to develop an AI-assisted laser capture microdissection (AI-LCM) approach for high-throughput, genome-wide spatial transcriptomics analysis. The project aims to optimize in-situ DNA nanoball generation and sequencing, enhance AI-assisted LCM to efficiently isolate single cells, and refine sequencing protocols to link genomic...
The National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), awarded a $301,161 project grant to Nest Health TECH Inc. (Nest Genomics) to develop, adapt, and refine the Nest platform for risk communication and disease management in families with hypertrophic cardiomyopathy (HCM). The 12-month project, commencing on September 22, 2025, will involve collaborating with Virginia Commonwealth University and the University of Iowa to create HCM-specific content and family sharing functionality within the Nest platform. The goal is to support patients with HCM and their at-risk relatives by providing guideline-driven information, clinical screening recommendations, and the ability to securely share genetic test results and other health information within families.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $301.2k | 9/19/25 |