Project Grant R41HG014101
- The National Human Genome Research Institute (NHGRI) awarded a $291,232 Project Grant to Micropure Genomics Inc. on September 17, 2025 under the Human Genome Research Federal Grant Program (CFDA 93.172). The project aims to develop an automated, bead-less, and gel-less microfluidic size selection approach to simplify workflows, reduce costs, and enhance the performance of long-read DNA sequencing technologies such as PacBio and Oxford Nanopore. The proposed innovation, called mPREP, leverages...
- The National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), awarded Evizia Inc. a $1,234,692 project grant on April 7, 2025. The grant supports the development of a novel biomolecule desktop imaging system called PRECYSE, which uses high-speed atomic force microscopy (HSAFM) to provide improved quality control for next-generation sequencing (NGS) sample preparation. The PRECYSE system can rapidly size DNA samples from 100 base...
- The National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), awarded a $384,418 Project Grant to Xgenomes Corp. on September 25, 2024 to develop a revolutionary DNA sequencing platform. The project aims to create a super-resolution single-molecule sequencing technology that can read short sequence "words" rather than individual nucleotides, enabling one or more orders of magnitude improvements in accuracy and cost over...
- This $383,482 Project Grant, awarded on June 6, 2025 by the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research), aims to develop SPINSEQ, an innovative RNA sequencing platform capable of precise and accurate transcriptomic analysis. The project, conducted by Electronic Biosciences, Inc., a small biotechnology company in San Diego, California, focuses on maintaining RNA integrity and enabling improved detection of RNA modifications through advanced sequencing...
- This Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research federal grant program (CFDA 93.172), will provide $215,088 to Directseq Biosciences, Inc. to develop an exhaustive de novo RNA sequencing method using next-generation mass spectrometry (NGMS-seq). The objective is to create a technology that can directly identify and sequence every RNA species in a sample, while also comprehensively profiling all RNA modifications, without bias....
- The National Human Genome Research Institute (NHGRI) awarded a $435,406 Project Grant (CFDA 93.172 - Human Genome Research) to the University of Colorado-Denver to explore new strategies for inferring protein-level changes from mRNA abundance measurements. The 2-year project aims to develop conceptual embeddings of proteins that capture information on protein-protein interaction networks and protein sequence, domain, and structure. These embeddings will be evaluated for their utility in...
- This $2,409,233 federal Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) supports the development of a suite of advanced statistical tools and user-friendly software to enhance the accuracy and reproducibility of single-cell and spatial omics data analysis. The key products and services to be delivered under this 4-year award include: Statistical methods to generate in silico data for use as negative controls and pseudo-replicates of...
- The National Human Genome Research Institute (NHGRI), under the Human Genome Research federal grant program (CFDA 93.172), awarded a $383,748 project grant to Jumpcode Genomics Inc. The grant supports the development of a CRISPR-based depletion technology to resolve pseudogene contamination in next-generation sequencing (NGS)-based genetic testing, with a focus on improving newborn screening (NBS) clinical tests. The goal is to enhance the sensitivity and specificity of detecting disease-causing...
- The National Human Genome Research Institute (NHGRI), under the Federal Grant Program for Human Genome Research (CFDA 93.172), awarded a $397,599 Project Grant to Xgenomes Corp. in Cambridge, MA. The grant supports the development of a novel epigenetic analysis method that can directly detect DNA methylation patterns across the genome with high accuracy, overcoming limitations of current sequencing techniques. The project aims to create advanced molecular analysis platforms that leverage machine...
- The National Human Genome Research Institute (NHGRI), under the Human Genome Research federal grant program (CFDA 93.172), awarded a $396,170 project grant to Syntaxisbio Inc. on September 17, 2025. The grant supports the development of an innovative technology using genetic PUFs (Physical Unclonable Functions) to precisely quantify the age and division/passage history of cell lines. This technology aims to address the critical challenge of reliable cell line identification and validation in...
The National Human Genome Research Institute (NHGRI), through its Human Genome Research Federal Grant Program (CFDA 93.172), awarded a $395,316 project grant to RTutor LLC (doing business as Orditus LLC) on September 4, 2025. The grant supports the commercialization of IDEP, an interactive and reproducible web-based tool for analyzing RNA sequencing (RNA-seq) data. The key products and services to be delivered under this grant include: 1) streamlining database updates for IDEP to automate annual updates from sources like Ensembl and STRING; 2) developing a desktop application version of the IDEP web server to enhance user experience, data security, and reproducibility; and 3) improving access to public RNA-seq data by adopting large language models to facilitate the reuse of published expression data. The project aims to transform IDEP, which has garnered over 650,000 website visits and 1,000 citations, into a commercially viable product through this partnership between RTutor LLC and South Dakota State University.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $395.3k | 9/4/25 |