This $306,499.00 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, will support the development and testing of an innovative oral regenerative therapy to improve wound healing in the oral cavity. The funding will allow the awardee, Oridivus LLC, to optimize and compare the immunoregenerative efficacy of an FTY720 nanofiber scaffold versus platelet-rich plasma (PRP) for promoting pro-regenerative inflammatory cell recruitment and improved vascularization in oral wound healing, using mouse and porcine animal models. The goal is to generate sufficient data to support a future Phase II clinical trial submission for the FTY720 nanofiber technology, which leverages an FDA-approved drug to potentially accelerate the clinical translation of this innovative oral regenerative therapy.
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