Project Grant R41AI197639
- The National Institute of Allergy and Infectious Diseases awarded Shabri, L.l.c. $306,864 on July 7, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop an antimicrobial prosthetic liner for preventing residual limb infection following major lower limb amputation. Residual limb infection occurs in approximately 3.9 to 12.9 percent of amputees and results from contamination at contact points between skin and the prosthetic liner. Severe infections may require...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded $599,327 to Microbiotix, Inc. on September 22, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop novel benzyl-piperidine antifungal agents targeting intractable mucormycosis infections caused by drug-resistant Mucorales fungi. The project focuses on chemical optimization of a benzyl-piperidine series to improve drug-like properties and...
- The National Institute of Allergy and Infectious Diseases awarded Prokaryotics Incorporated $299,697 on September 19, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop a mechanistically novel antifungal agent targeting cell wall β-1,3-D-glucan biosynthesis with broad-spectrum activity against pathogenic yeasts and molds, including echinocandin-resistant strains. The project runs through February 28, 2027, with performance in Union, New Jersey. Phase 1...
- The National Institute of Allergy and Infectious Diseases awarded the University of Massachusetts $2,641,186 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop antimicrobial poly(oxanorborneneimide) polymers (PONI-AMPs) for treating multidrug-resistant wound biofilm infections. The research integrates synthetic chemistry, atomistic computational modeling, and machine learning to evolve PONI-AMP therapeutics. Initial work demonstrated 99...
- The National Institute of Allergy and Infectious Diseases awarded the University of Maryland, Baltimore $233,250 on June 26, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop plant-derived nanoparticles as a sepsis immunotherapy. The recipient is engineering bio-inspired lipid nanoparticles capable of mitigating the excessive inflammatory response that drives poor outcomes in sepsis, a life-threatening immune response to infection that causes systemic...
- The National Institute of Allergy and Infectious Diseases awarded the Regents of the University of Michigan $234,000 on August 14, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop sustainable production and derivatization of premarineosin A, a potent antimalarial compound. The project establishes premarineosin A as a next-generation antimalarial agent by developing metabolic engineering strategies to achieve sustainable production of the compound and...
- Federal Project Grant Award Summary Halomine Inc. (doing business as Avantguard) received a $299,435 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop and optimize a novel, bio-inspired chloramine-based antifungal treatment for cutaneous fungal infections. The award, effective August 1, 2025 through July 31, 2026, supports the advancement of a stabilized chloramine polymer...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded Virginia Polytechnic Institute & State University $733,233 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop novel nitroxoline analogs for oral treatment of drug-resistant Neisseria gonorrhoeae and Chlamydia. The project addresses the dual public health challenge posed by these sexually transmitted infections....
- The National Institute of Allergy and Infectious Diseases, a component of the Department of Health and Human Services, awarded $148,614 to Massachusetts Institute of Technology on January 14, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The recipient will develop glycopolymers designed to enhance interactions between immune cells and pathogenic bacteria, creating "cellular glues" that leverage the body's innate immune mechanisms as an alternative to...
- The National Institute of Allergy and Infectious Diseases awarded the University of California, San Diego $720,035 on February 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop living microrobot therapeutics for treating severe multidrug-resistant pulmonary infections. The project centers on designing and validating a microrobot platform consisting of Chlamydomonas reinhardtii microalgae modified with neutrophil membrane-coated, drug-loaded polymeric...
The National Institute of Allergy and Infectious Diseases awarded Chitozan Health, LLC $320,600 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop innovative flame-retardant antimicrobial textiles for healthcare and protective applications. Chitozan Health will develop a dual-function textile finish combining antimicrobial and flame-retardant properties by leveraging chitosan and 0.25-micron silver chloride particles. The work involves phosphorylating chitosan hydroxyl groups and integrating phosphate ions into silver chloride crystal lattice through novel precipitation chemistry, followed by evaluation of coated materials for antimicrobial efficacy, durability, and flame resistance against regulatory standards. The recipient will scale up to a pilot coating machine and assess manufacturing feasibility. The research targets applications in medical facilities, military field hospitals, children's clothing, and nursing homes. The project builds on prior work demonstrating that the antimicrobial finish kills harmful bacteria and airborne fungus while preventing microbial resistance development—a property critical to combating antimicrobial-resistant pathogens. Current flame-retardant textile finishes face EPA scrutiny for potential health and environmental toxicity, making a safer alternative with dual functionality commercially relevant. The University of Georgia serves as a research partner. Work is performed in Rochester, New York, with performance concluding August 31, 2027. The award is classified as a Project Grant, an assistance type supporting research on infectious diseases and related areas.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $320.6k | 9/1/26 |