Project Grant R37CA307677
- Federal Grant Award Summary The University of Pennsylvania received a $703,071 Project Grant award from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), effective April 10, 2026, through March 31, 2031. This research initiative investigates the determinants of long-term chimeric antigen receptor T cell (CAR-T) persistence in patients with previously untreatable blood cancers. The project delivers fundamental research aimed at understanding why some...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the University of Pennsylvania a Project Grant of $148,626 under the Cancer Research Manpower program (CFDA 93.398), effective December 1, 2025, through April 30, 2028. This award supports research training and investigator development in cancer research aligned with the National Cancer Program's strategic priorities. The funding enables the institution to provide biomedical training opportunities and research career...
- Federal Project Grant Award Summary The University of Pennsylvania received a $667,041 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), effective April 1, 2026 through February 28, 2031. This five-year research initiative focuses on the validation and credentialing of patient-derived xenograft (PDX) models of hepatocellular carcinoma (HCC) using patient-level clinical data. The project addresses a critical gap in preclinical...
- Federal Grant Award Summary The University of Pennsylvania received a $109,076 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398), awarded January 30, 2026, with completion targeted for July 29, 2027. This award supports biomedical research training and investigator development in cancer research aligned with the National Cancer Program's strategic priorities. The grant funds research into metabolic crosstalk between pancreatic cancer...
- Federal Grant Award Summary The National Cancer Institute awarded a $122,610 Project Grant to the University of Pennsylvania on August 11, 2025, under the Cancer Treatment Research program (CFDA 93.395). The award, with a completion date of July 31, 2030, supports the development of a system to advance National Cancer Institute (NCI)-sponsored clinical trials for patients with rare gastrointestinal malignancies and rare disease populations. The project leverages the principal investigator's...
- Federal Project Grant Award Summary The University of Pennsylvania received a $160,040 Project Grant award from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398), effective January 16, 2026, with a completion date of July 31, 2027. The award supports research investigating the therapeutic potential of Dectin-1 activation for treating gastrointestinal stromal tumors (GISTs), particularly in cases resistant to imatinib therapy. The project leverages innate...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the University of Virginia a $192,887 Project Grant under the Cancer Research Manpower program (CFDA 93.398) beginning May 8, 2026, with an ultimate completion date of April 30, 2029. This award supports biomedical research and training focused on sphingolipid-guided stratification and therapeutic opportunities in acute myeloid leukemia (AML). The project delivers research services aimed at improving AML risk...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the University of Pennsylvania a Project Grant totaling $513,542 on June 15, 2025, under the Cancer Biology Research program (CFDA 93.396) to conduct fundamental research on the role of p53 in regulating chaperone-mediated autophagy (CMA) and its implications for tumor suppression. The research project, scheduled for completion by May 30, 2030, aims to define the mechanisms by which p53 regulates CMA—a highly...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The University of Pennsylvania $178,893.00 under the Cancer Treatment Research program (CFDA 93.395) as a Project Grant effective September 1, 2025, through August 31, 2030. The award supports Dr. Naomi Haas's initiatives to develop and advance immunotherapy clinical trials in renal cell cancer (RCC) for potential integration into the National Clinical Trials Network (NCTN). As a genitourinary medical oncologist and Renal...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Trustees of The University of Pennsylvania a Project Grant totaling $126,220 under the Cancer Research Manpower program (CFDA 93.398) to support research and training activities in cancer biology. The award, obligated on September 10, 2025, with a completion date of May 31, 2026, funds an investigator-initiated research project titled "Mechanisms of Lymphatic Metastasis in Pancreatic Ductal...
The University of Pennsylvania received a $434,969 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), effective May 1, 2026 through April 30, 2031. This award funds research investigating Type I interferon response and differentiation mechanisms in FLT3 (Fms-like tyrosine kinase 3)-inhibitor persistent acute myeloid leukemia (AML). The project deliverables include mechanistic studies identifying which leukemic cells propagate disease and survive targeted FLT3 inhibitor therapy, utilizing genetically engineered mouse models with multi-recombinase systems, serial transplantation assays, and functional cell ablation studies integrated with human specimen analysis. The research addresses critical gaps in understanding AML relapse following FLT3-targeted treatment, with specific aims to identify cellular reservoirs of leukemic stem cell activity and characterize the molecular pathways underlying FLT3-mutant clone persistence. Preliminary findings indicate that FLT3 inhibition triggers profound cell differentiation and Type I interferon signaling, which the research will elucidate through integrative studies designed to translate mechanistic observations from model systems into clinically meaningful insights for improving treatment outcomes in AML patients who currently experience high relapse rates despite initial therapeutic responses.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $435.0k | 4/29/26 |