Project Grant R37CA304011
- The National Cancer Institute awarded Dana-Farber Cancer Institute, Inc. $235,491 on May 1, 2026, under the Cancer Research Manpower program (CFDA 93.398) to support research training and career development in cancer research. The award funds investigation into high-count monoclonal B-cell lymphocytosis (HC-MBL) and its relationship to mosaic chromosomal alterations, particularly deletions in chromosome 13q and trisomy 12. The research will examine phenotypic consequences of HC-MBL across two...
- The National Cancer Institute, part of the Department of Health and Human Services National Institutes of Health, awarded Albert Einstein College of Medicine $431,970 under the Cancer Treatment Research program (CFDA 93.395) on April 1, 2026, to investigate combination approaches to acute myeloid leukemia targeting both CD123-directed NK cell engagers and BCL-2 inhibition through venetoclax. The research will employ dynamic BH3 profiling to probe mitochondrial priming mechanisms and test whether...
- The National Cancer Institute awarded Dana-Farber Cancer Institute, Inc. $2.433959 million on August 13, 2026, under the Cancer Centers Support Grants program (CFDA 93.397), with performance concluding July 31, 2031, at the recipient's Boston, Massachusetts location. The award funds a Specialized Program of Research Excellence (SPORE) in Leukemia designed to improve understanding of the genetic and molecular basis of myeloid leukemia and acquired resistance to treatment, and to develop novel...
- The National Cancer Institute awarded Dana-Farber Cancer Institute, Inc. $233,478 on September 1, 2026, under the Cancer Research Manpower program (CFDA 93.398) to characterize and target acquired resistance to menin-KMT2A inhibitors in acute myeloid leukemia. The award funds research profiling patient samples and patient-derived xenograft models to identify gain-of-function mutations in an oncogenic chromatin complex composed of menin, KMT2A, and PSIP1 proteins that confer resistance to menin...
- The National Cancer Institute awarded Dana-Farber Cancer Institute, Inc. $1.547 million in project grant R37CA295653 on September 17, 2025, under the Cancer Detection and Diagnosis Research program (CFDA 93.394). Dana-Farber will develop and deploy ACTIVATE, an open-source AI-driven tool to improve cancer clinical trial feasibility assessment and patient-trial matching. The tool extends Dana-Farber's existing MatchMiner platform to extract clinical variables—including cancer type, stage,...
- The National Cancer Institute awarded Dana-Farber Cancer Institute, Inc. $528,099 on September 1, 2026, under the Cancer Treatment Research program (CFDA 93.395) to characterize therapeutic vulnerabilities in ovarian clear cell carcinoma and develop new treatment strategies for both ARID1A-mutant and ARID1A-wildtype disease. The funded research identifies the PI3K/mTOR and HIF/VEGF pathways as fundamental therapeutic targets in ovarian clear cell carcinoma, with particular focus on synergy...
- The National Cancer Institute awarded Dana-Farber Cancer Institute, Inc. $432,050 on August 17, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop peptide-MHC pseudotyped retroviral vectors for in vivo gene delivery to antigen-specific T cells as a novel cancer immunotherapy approach. The work addresses a gap in current cancer immunotherapies by combining attributes of CAR-T cell therapies with tumor-infiltrating lymphocyte and immune checkpoint blockade...
- The National Cancer Institute awarded Dana-Farber Cancer Institute $643,414 on August 1, 2026, under the Cancer Treatment Research program (CFDA 93.395) to develop an interleukin-21 mimic compound, designated 21H10, that enhances anti-tumor immunity in pancreatic ductal adenocarcinoma. The research centers on combining 21H10 with KRAS inhibitors to convert transient therapeutic responses into durable remissions in pancreatic cancer. The compound was developed using AI-assisted computational...
- The National Cancer Institute awarded Brigham & Women's Hospital Inc. $409,463 on June 16, 2026, under the Cancer Treatment Research program (CFDA 93.395) to evaluate eukaryotic translation initiation factor 4A (EIF4A) inhibition as a therapeutic approach for acute myeloid leukemia. The research validates zotatifin, a clinical-grade EIF4A inhibitor, as a small molecule to target AML cells. The central hypothesis is that zotatifin selectively targets AML cells over healthy cells and...
- The National Cancer Institute awarded Emory University $639,859 under the Cancer Treatment Research program (CFDA 93.395) on May 1, 2026, to support research targeting non-genetic and genetic mechanisms of drug resistance in acute myeloid leukemia. The research addresses how most AML patients develop resistance to chemotherapy or targeted therapy, leading to relapse and death. The project applies dynamic BH3 profiling and patient-derived xenograft models to understand how resistance emerges,...
The National Cancer Institute awarded Dana-Farber Cancer Institute, Inc. $388,616 on September 1, 2026, under the Cancer Treatment Research program (CFDA 93.395) to conduct prospective clinical validation of dynamic BH3 profiling as a functional biomarker for guiding treatment selection in patients with relapsed or refractory acute myeloid leukemia. The project develops and tests a novel assay that measures changes in apoptotic priming in leukemia cells after short ex vivo drug exposure. Dynamic BH3 profiling has shown predictive value in preclinical and retrospective clinical studies for response to venetoclax (a BCL-2 inhibitor), targeted therapies, and chemotherapy, but lacks prospective clinical validation. The work addresses a critical gap in AML management: current mutation testing guides therapy for only 50 percent of relapsed patients, and the majority do not achieve complete remission with single-agent targeted approaches. This assay aims to provide patient-specific mitochondrial drug-sensitivity data to optimize combination therapy selection and improve remission rates. Performance of work occurs in Boston, Massachusetts, with a project period running through August 31, 2031. Dana-Farber Cancer Institute, a nonprofit academic medical research organization affiliated with Harvard Medical School, serves as the grant recipient and leads the research effort.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $388.6k | 9/1/26 |