Project Grant R37CA295784
- This federal Project Grant award from the National Cancer Institute (CFDA 93.395 Cancer Treatment Research) provides $198,103 to New York University School of Medicine to investigate the role of the immune microenvironment in melanoma bone metastasis. The research aims to define the mechanisms by which melanoma cells colonize the skeletal system and modify the bone microenvironment, as well as explore the interplay between tumor, skeletal, and immune cells during melanoma bone metastasis. The...
- This Project Grant award from the National Cancer Institute (NCI), under the federal Cancer Biology Research program (CFDA 93.396), provides $442,236 to the University of Alabama at Birmingham (UAB) from January 1, 2025 through December 31, 2029. The funding supports research to uncover a novel melanoma metastasis pathway driven by the YTHDF1 RNA-binding protein, and to evaluate therapeutic targeting of the IMPDH1 and TRKB/BDNF pathways that mediate this process. The research utilizes...
- This Project Grant award for $679,604.00 was provided by the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) to The Children's Hospital Corporation (Boston Children's Hospital) to evaluate pathways involved in the initiation and formation of melanoma using a zebrafish model. The research aims to reveal critical pathways that participate in melanoma development and progression, with the goal of advancing scientific knowledge to improve prevention, diagnosis,...
- This $673,526 federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research at the University of Pittsburgh to investigate the mechanistic role of the p16 tumor suppressor gene in regulating zinc homeostasis and its impact on immune checkpoint blockade (ICB) therapy resistance in melanoma. The key objectives are to: 1) Interrogate how p16 loss and altered zinc transporter SLC39A9 expression attenuate cGAS-STING signaling and downregulate...
- The National Cancer Institute (CFDA 93.396 - Cancer Biology Research) awarded a $510,431 Project Grant to The Johns Hopkins University to conduct research on recurrence and resistance in the aging melanoma microenvironment. The research aims to uncover how the aging immune microenvironment influences tumor dormancy and therapeutic resistance in melanoma. Key focus areas include understanding the role of aged lung fibroblasts and their impact on melanoma cell dormancy and reactivation through Wnt...
- This $521,579 Project Grant award, provided by the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), supports research to identify critical regulators controlling clear cell renal cell carcinoma (CCRCC) lung metastasis. The University of Texas Southwestern Medical Center, the awardee, will conduct a genome-wide CRISPR screen to characterize the role of the hepatic leukemia factor (HLF) in CCRCC lung metastasis and examine the underlying molecular...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $646,739.00 in funding to Cedars-Sinai Medical Center to investigate the molecular mechanisms underlying the role of hepatic stellate cells (HSCs) in promoting liver metastasis, particularly in the context of metabolic dysfunction-associated steatotic liver disease (MASLD). The key research objectives are to: 1) examine the regulatory mechanism and functional role of extra-tumoral...
- This Project Grant award of $395,509 from the National Cancer Institute's Cancer Biology Research Program (CFDA 93.396) supports research by the Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Boston, Massachusetts. The project aims to investigate the regulatory mechanisms and pathological roles of the SKP2 oncogenic E3 ubiquitin ligase in melanoma development and progression. Specifically, the research seeks to: 1) understand how SKP2 protein stability is regulated by its upstream E3...
- This Project Grant award from the National Cancer Institute (NCI), part of the U.S. Department of Health and Human Services, is funded under the Cancer Research Manpower (CFDA 93.398) program. The $216,460 award to Case Western Reserve University will support research to investigate the epigenetic drivers of lung metastasis in osteosarcoma. The project aims to study the key transcription factors and chromatin state changes that enable lung colonization by osteosarcoma cells, with the goal of...
- This federal Project Grant award for $2,679,816.00, provided by the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), supports four integrated research projects that aim to address key aspects of mutant p53 and its role in tumor metastasis. The funded research, led by principal investigator James Manfredi, focuses on systematic studies of mutant p53 allelic variation, mechanisms of the hot-spot mutant p53R175H in tumor metastasis, defining the roles of mutant p53...
This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $487,468 to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to conduct research on the role of protein palmitoylation in the progression of melanoma lung metastasis. The key objectives of the research project are to: This 5-year research project aims to advance the understanding of cancer metastasis mechanisms and identify potential new therapeutic targets for the treatment of metastatic melanoma, which has a poor 5-year survival rate of 15-20% in advanced stages.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $487.5k | 8/25/25 |