This $592,866 Project Grant was awarded by the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to the Georgia Tech Research Corporation. The grant aims to develop ingestible nanosensors engineered to detect enzymes in the intestinal mucosa that are associated with colorectal cancer development. The nanosensors will be designed to release volatile reporters upon detecting these enzymes, which can then be analyzed in breath samples using mass spectrometry. This breath-based biomarker approach seeks to provide a non-invasive, sensitive method for early-stage colorectal cancer detection, addressing limitations of current screening tests. The award has a project period from March 2025 to February 2030, with the goal of validating this nanosensor platform in animal models to potentially enable broader application for gastrointestinal disease detection.
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