The Trustees of the University of Pennsylvania, through its Clinical Practices division, was awarded a $580,045 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) on August 1, 2024. This grant will fund research to investigate the role of the chromatin methyltransferase DOT1L in neurodevelopmental disorders. The project aims to define how disruption of DOT1L and the associated histone 3 lysine 79 methylation mark impact neuronal function, transcription, and brain development. The research will leverage biochemical studies, genome-wide sequencing, and mouse and cell line models to elucidate the mechanisms by which DOT1L regulates cognition and neuronal maturation. The findings are expected to advance the understanding of an emerging neurological disorder and the epigenetic regulation of brain function.
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