Project Grant R35GM166480
- The National Institute of General Medical Sciences awarded the Regents of the University of Minnesota $398,144 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to engineer immunocompetent tissue models for studying inflammatory disease mechanisms. The research combines human pluripotent stem cells and genetic engineering to create microtissues containing tissue-resident macrophages with controllable inflammatory states. The project targets skeletal...
- The National Institute of General Medical Sciences awarded $492,931 to the Regents of the University of Minnesota on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop multiplexed assays of variant effect (MAVE) pipelines that integrate cellular context into synthetic protein engineering. The award funds research to advance understanding of how protein molecular traits—including folding stability and trafficking—function across different cell...
- The National Institute of General Medical Sciences awarded the Regents of the University of Minnesota $423,500 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop advanced mass spectrometry platforms for assessing structural stability in biotherapeutics. The funded work will create integrated mass spectrometry methods—combining native mass spectrometry, ion mobility-mobility mass spectrometry, charge detection mass spectrometry, and controlled...
- The National Institute of General Medical Sciences awarded the Regents of the University of Minnesota $333,290 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a comprehensive analytical framework for integrative analysis of high-throughput biomedical data across multiple sources, dimensions, and sample cohorts. The recipient will develop flexible statistical methodology and software for bidimensional regression and factorization that...
- The National Institute of General Medical Sciences awarded Regents of the University of Minnesota $373,737 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on the dynamics of motile flagella in fluid media. The recipient will develop new physical model systems and advanced imaging techniques to elucidate fluid-mediated flagellar dynamics in two critical research areas: resolving the synchronized dynamics of prokaryotic flagella...
- The National Institute of Biomedical Imaging and Bioengineering awarded the Regents of the University of Minnesota $471,967 on May 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award funds development of dual density-dependent molecular AND gates—engineered targeting ligands that selectively bind cells expressing high levels of two distinct antigens via bispecific avidity. The research addresses on-target,...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded $366,517 to the Regents of the University of Minnesota on August 6, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds investigation of myosin-based mechanisms in filopodia formation. The research examines how filopodia—dynamic, actin-rich cellular projections that enable cell navigation, intercellular contact...
- The National Institute of General Medical Sciences awarded $423,500 to the Regents of the University of Minnesota on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop universal genetic reagents and high-throughput transgenesis methods for natural product drug discovery from microbial genomes. The project, titled "TERPENE: Titer Enhancement via Refactored Precursor Pathways for Natural Produce Discovery," addresses bottlenecks in...
- The National Institute of General Medical Sciences awarded the Regents of the University of Minnesota $386,879 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the mechanisms governing nucleosome dynamics and epigenetic inheritance during cell division. The research examines how parental histones transfer to newly replicated DNA strands during DNA replication and how this transfer regulates replication fork recovery under stress conditions....
- The National Institute of General Medical Sciences awarded the Regents of the University of Minnesota $437,250 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct integrative structural biology research on measles virus RNA synthesis machinery. The funded work will determine the structural and functional properties of the measles virus polymerase complex in various functional states including initiation, elongation, and termination; explore the...
The National Institute of General Medical Sciences awarded the Regents of the University of Minnesota $404,165 on July 23, 2026, through the Biomedical Research and Research Training program (CFDA 93.859) to advance cryoimaging techniques for visualizing cellular communication mechanisms. The research applies in situ correlative cryoimaging to decode the molecular architecture of juxtacrine signaling, using the Notch pathway as a primary model system. The work aims to directly image Notch-ligand complexes at cell-cell interfaces to resolve longstanding questions about the mechanism of action in crowded cellular environments. The project also develops next-generation tools for precision image registration in multimodal cryoimaging by engineering genetically-encoded, intracellular fiducial markers based on vault ribonucleoproteins—termed "microscopic beacons"—to provide robust reference points for cryogenic correlative light and electron microscopy workflows and improve targeting accuracy. Performance occurs in Minneapolis, Minnesota. The period of performance extends through May 31, 2031. The assistance type is a Project Grant, a form of investigator-initiated basic research funding that NIGMS uses to support research increasing understanding of biological processes and laying foundation for advances in disease diagnosis, treatment, and prevention.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $404.2k | 7/22/26 |