Project Grant R35GM165652
- Federal Project Grant Award Summary The University of North Carolina at Chapel Hill received a $470,963 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective May 1, 2026, through April 30, 2031. This award supports research focused on enhanced sampling of intracellular protein interactions between G-protein-coupled receptors (GPCRs) and their binding partners, specifically...
- Federal Project Grant Award Summary The University of North Carolina at Chapel Hill received a $413,946 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded April 5, 2026, with completion targeted for February 28, 2031. The grant funds fundamental research to elucidate the molecular determinants of functional specificity in intrinsically disordered proteins (IDPs), with particular focus on...
- Federal Project Grant Award Summary The University of North Carolina at Chapel Hill received a $533,425 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded July 15, 2026, with completion targeted for May 31, 2030. The award funds investigator-initiated basic biomedical research to define new regulatory mechanisms and functional roles of the E3 ligase protein RNF25 in DNA replication...
- Federal Project Grant Award Summary The University of North Carolina at Chapel Hill received a $2,257,345 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) for the period September 1, 2025 through August 31, 2029. The award supports the development of next-generation microscopy instrumentation and computational methods to advance biological research across spatiotemporal scales. The project will...
- Federal Project Grant Award Summary The University of North Carolina at Greensboro received a $1.33 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded April 1, 2026, with completion targeted for March 31, 2030. The project develops cost-effective analytical workflows for unsaturated lipidomics by extending a novel ion chemistry method called OZNOXESI (ozone-induced...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $474,507 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective April 1, 2026 through March 31, 2031. The award supports fundamental research investigating cell signaling through O-linked glycosylation, with particular emphasis on O-linked β-N-acetylglucosamine (O-GlcNAc), a ubiquitous...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) awarded UC San Diego a $369,347 Project Grant beginning July 1, 2026, and extending through June 30, 2031, to conduct high-resolution structural analysis of megasynthases using cryo-electron microscopy (cryo-EM). The primary deliverables include development and application of molecular tools and probes to enable structural...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $375,996 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective July 1, 2026 through June 30, 2030. The award supports research to develop advanced protein language models (PLMs) that improve computational predictions of protein function and design. The project delivers three primary research...
- Federal Grant Award Summary Duke University received a $737,152 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 10, 2026, with a completion date of December 31, 2030. This award supports fundamental research into the functions and mechanisms of metalloenzymes involved in natural product and cofactor biosynthesis. The research integrates two ongoing NIGMS R01 projects...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded $420,492 to the Regents of the University of California at Riverside under the Biomedical Research and Research Training program (CFDA 93.859) on July 10, 2026, for a five-year project extending through April 30, 2031. The award funds the development of novel chemical synthesis strategies and biological evaluation of natural product-derived compounds targeting three disease-associated protein...
The National Institute of General Medical Sciences (NIGMS) awarded the University of North Carolina at Chapel Hill $427,625 under the Biomedical Research and Research Training program (CFDA 93.859) on August 1, 2026, for a project extending through March 31, 2031. This Project Grant supports fundamental molecular and structural biology research characterizing serotonin-2C receptor (5-HT2CR) isoforms and their signaling patterns. The research program delivers comprehensive analysis of all 24 naturally occurring 5-HT2CR protein isoforms generated through adenine-to-inosine RNA editing, utilizing cryo-electron microscopy, molecular dynamics simulations, and functional biosensor assays to map isoform-specific activation patterns across G-protein subtypes in response to a library of 21 chemically diverse agonists. The project generates scientific knowledge products including structural characterization of receptor-ligand interactions, computational modeling of receptor conformational dynamics across isoforms, and functional coupling data mapping isoform-specific signaling selectivity. These deliverables advance understanding of G-protein-coupled receptor (GPCR) signaling mechanisms, molecular determinants of functional selectivity, and transducer coupling specificity—foundational insights supporting future advances in drug development and disease treatment relevant to serotonin receptor function.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $427.6k | 7/16/26 |