Project Grant R35GM165577
- The National Institute of General Medical Sciences awarded Boston Children's Hospital $2.563 million on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to expand the biological capabilities of image-based transcriptomics by targeting short, homologous, and synthetic transcripts. The award funds development of multiplexed error-robust fluorescence in situ hybridization (MERFISH) methodology to overcome three key limitations of current image-based...
- The National Institute of General Medical Sciences awarded the Trustees of Boston University $433,750 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop network-based computational models for understanding continuous cell states in human development and disease. Over five years through February 28, 2031, the research group will create methods to integrate multiple modalities of large-scale genomics data, with emphasis on epigenetics and the...
- The National Institute of General Medical Sciences awarded the University of Massachusetts Medical School $460,625 on March 12, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to uncover fundamental principles of transcriptional regulation in the model bacterium E. coli. The project systematically measures the function and occupancy of transcription factors to parameterize a predictive model of gene regulation. The research exploits a library of E. coli strains...
- The National Institute of General Medical Sciences awarded the University of Massachusetts Medical School $460,625 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop machine learning methods that model cis- and trans-regulatory drivers of chromatin accessibility from single-cell multiomic datasets. Over the five-year period of performance through May 31, 2031, the recipient will create machine learning approaches that simultaneously account...
- The National Institute of General Medical Sciences, a component of the Department of Health and Human Services, awarded $440,465 to the Massachusetts Institute of Technology on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop biophysical models of genome folding and function. Over the five-year performance period ending February 28, 2031, the award funds research into chromosome architecture and the mechanisms that shape it—motor-driven loop...
- Federal Project Grant Award Summary Boston Children's Hospital received a $1.27 million Project Grant (R01) from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective August 1, 2025 through July 31, 2027. The award supports collaborative research investigating the mechanisms through which transposable element (TE) mobilization and disrupted messenger RNA (mRNA) translation impair neural progenitor cell (NPC)...
- The National Institute of Biomedical Imaging and Bioengineering awarded Massachusetts Institute of Technology $678,583 on May 14, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop synthetic genetic controller circuits that autonomously regulate transcription factor expression to direct cell differentiation. The project, led by Principal Investigator Domitilla del Vecchio with co-investigators James J. Collins and...
- The National Institute of General Medical Sciences awarded President and Fellows of Harvard College $165,279 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research dissecting the control of transcription elongation by RNA polymerase II and coordinated messenger RNA processing in gene expression regulation. The research investigates how promoter-proximal pausing and release of RNA polymerase II (RNAPII) control metazoan gene expression,...
- The National Institute of Allergy and Infectious Diseases awarded The Children's Hospital Corporation (doing business as Boston Children's Hospital) $267,000 on July 6, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate regulatory B cell function in transplant alloimmunity. The project examines whether neuropilin-2 (NRP2)-expressing B cell subsets promote immunoregulation and suppress CD4+ T effector cell activation in the context of organ transplant...
- The National Institute of General Medical Sciences awarded The General Hospital Corporation (Massachusetts General Hospital) $453,750 under the Biomedical Research and Research Training program (CFDA 93.859) on August 1, 2026, through Project Grant R35GM165865. The award funds research investigating how mitochondrial metabolism regulates species-specific developmental rates in mammalian embryos. The research program uses an in vitro system that recapitulates the two- to threefold difference in...
The National Institute of General Medical Sciences awarded The Children's Hospital Corporation (Boston Children's Hospital) $489,500 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support quantitative decoding of transcriptional regulation in development and evolution. The award funds research that develops and applies chemical genetic approaches to precisely modulate transcription factor dosage in human pluripotent stem cell–derived cell types. The work defines how dosage of the transcription factors SOX2, SOX9, and TWIST1 modulates chromatin state, gene expression, and cellular phenotypes, and how this dosage-dependent regulation varies across cell types and evolutionary time. The research employs deep learning models to identify sequence features underlying variation in regulatory element dosage responses, with particular focus on low-affinity binding motifs. The transcription factors selected are associated with dosage-sensitive developmental disorders, function in multiple cell types, and show evidence of regulatory evolution. Place of performance is Boston, Massachusetts. The period of performance runs from August 1, 2026, through May 31, 2031. This is a Project Grant, the standard assistance type under NIGMS's biomedical research portfolio supporting investigator-initiated basic research that advances understanding of biological processes and lays the foundation for disease diagnosis, treatment, and prevention advances.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $489.5k | 7/29/26 |