Project Grant R35GM164259
- The National Institute of General Medical Sciences awarded The Ohio State University $441,570 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to explore actin cytoskeleton organization and function in health and disease. The project runs through April 30, 2031, with performance at Columbus, Ohio. The research advances understanding of how actin-binding proteins called plastins organize actin filaments into higher-order assemblies—bundles and networks—and...
- This three-year $300,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences will support research into the molecular mechanisms governing cell membrane repair. Funded under the Biological Sciences program (CFDA 47.074), the grant aims to advance understanding of major problems in the biological sciences through basic research. Specifically, the principal investigator will conduct nonlinear surface spectroscopic investigations at Oregon State...
- The National Institute of Allergy and Infectious Diseases awarded The Ohio State University $775,022 in Project Grant R01AI191704 on June 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research into plasma membrane repair mechanisms in cells injured by bacterial pore-forming toxins known as cholesterol-dependent cytolysins, which are produced by major gram-positive pathogens including Listeria monocytogenes, Streptococcus pneumoniae,...
- The National Institute of General Medical Sciences awarded The Ohio State University $403,373 on July 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on the molecular mechanisms of circadian gene regulation. The research addresses how a single 24-hour circadian oscillator supports multiphasic gene expression across organisms. The project integrates in vitro biochemical assays with genetic tools in the cyanobacterium Synechococcus...
- Federal Project Grant Award Summary The Ohio State University received a $416,726 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 11, 2025, with completion targeted for August 31, 2030. The project focuses on developing mass spectrometry-based technologies to enable chemical analysis of organoids—three-dimensional cell cultures derived from human or animal tissues—with...
- Federal Project Grant Award Summary The Ohio State University received a $2,130,924 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2029. This award supports fundamental research into developmental regulation of oscillatory gene expression, specifically investigating the segmentation clock mechanism that controls somitogenesis—the...
- The National Institute of General Medical Sciences awarded Fred Hutchinson Cancer Center $613,838 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanisms of dynamic cytoskeleton and membrane interactions critical for cell survival and repair. The research focuses on how cells rapidly repair injuries to the plasma membrane and nuclear envelope caused by physiological stress, trauma, infection, or disease. The principal investigator's...
- The National Institute of General Medical Sciences awarded The Ohio State University $410,893 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct genomics-accelerated discovery and biosynthesis research on phosphonic acid natural products. The project, identified as R35GM161629, runs through December 31, 2030, with performance at Columbus, Ohio. The research program aims to discover microbial natural products of chemotherapeutic value, establish...
- The National Institute of General Medical Sciences awarded The Ohio State University $382,823 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a label-free analytical method for imaging biomarker distribution in soft tissues. The project introduces silicon-based light-enabled active potentiometry (SILEAP), a mechanically flexible, ultrathin electronic interface constructed from an unpatterned SiO₂/Si bilayer designed to enable spatially...
- The National Institute of General Medical Sciences awarded The Ohio State University $383,169 on July 23, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop AI-powered computational models for translational research that benchmark the fidelity of animal models and organoid systems against human references and construct ensemble virtual cells to predict human cellular responses under perturbations. The award funds two integrated research directions....
The National Institute of General Medical Sciences awarded The Ohio State University $416,838 on August 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on the molecular mechanisms of cytokinesis and plasma membrane repair. The recipient will conduct fundamental studies using fission yeast as a model system to reveal how cells divide and repair damage to the plasma membrane, focusing on the coordination of cytoskeleton remodeling, organelle partitioning, membrane dynamics orchestrated through exocytosis and endocytosis, and the molecular pathways that restore cell integrity following membrane injury. The research spans cytokinesis mechanisms including division-site selection, actomyosin contractile-ring assembly, ring constriction and disassembly, plasma-membrane invagination and expansion, and daughter-cell separation, as well as plasma membrane repair pathways including calcium signaling, vesicle trafficking, Rho GTPase activation, and endocytosis. Performance occurs in Columbus, Ohio, with a period of performance extending through May 31, 2031. This project grant supports investigator-initiated basic research that builds on the recipient's published results and preliminary data to advance understanding of fundamental cellular processes relevant to cell proliferation, differentiation, and tissue homeostasis.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $416.8k | 8/10/26 |