Project Grant R35GM164113
- The National Institute of General Medical Sciences awarded the University of Illinois $113,211 on September 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop mass spectrometry-based instrumentation and computational tools for spatiotemporal neuropeptidomics with isomer-resolved capabilities. The work will map neuropeptide distribution and release with high spatial and temporal resolution and increased throughput, creating new molecular signatures of...
- The National Institute of General Medical Sciences awarded the University of Illinois $372,016 on July 7, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to deconstruct RNA polymerase III regulation and function through systematic profiling of POL III activity and discovery of new regulatory mechanisms. The research applies genomic and biochemical strategies to characterize POL III transcription breadth and tissue-specific patterns, focusing initially on the...
- The National Institute of General Medical Sciences awarded the University of Illinois $1,385,652 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop in vivo metabolic tagging and targeting of long-circulating red blood cell biomembranes. The project aims to create a platform technology for metabolic tagging of red blood cell (RBC) membranes using unnatural sugars and subsequent targeting of molecular imaging and therapeutic cargo via click...
- The National Institute of General Medical Sciences awarded $338,892 to the University of Illinois on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for organometallic chemistry research on nickel enzymes. The project focuses on developing catalytic and functional mimics of acetyl-coenzyme A synthase (ACS) and [NiFe] hydrogenase through the design of flexible multidentate ligands with mixed hard/soft donor atoms. The research aims to detect and...
- The National Institute of General Medical Sciences awarded the University of Illinois $2,101,232 on August 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop quantitative computational approaches that probe diverse biological processes and relate their outcomes to molecular structure and motion. The project will develop computational methods ranging from atomistic molecular dynamics to continuum simulations, guided by unmet needs in basic biomedical...
- The National Institute of General Medical Sciences awarded the University of Illinois $453,722 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to discover and characterize novel microbial enzymes capable of converting host steroids and steroid pharmaceuticals into androgen compounds. The research focuses on steroid biotransformations by host-associated bacteria in human stool and urine samples. The investigator team will continue characterizing...
- The National Institute of General Medical Sciences, a component of the Department of Health and Human Services National Institutes of Health, awarded the University of Illinois $614,467 on April 1, 2026, through the Biomedical Research and Research Training program (CFDA 93.859) to develop switchable artificial metalloproteins (SWARMs) that model conformational control in metalloenzyme reactivity. The research, led by principal investigator Lisa Olshansky, combines synthetically prepared metal...
- The National Institute of General Medical Sciences awarded the University of Illinois $415,788 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate phosphoinositide regulation of Rho guanine nucleotide exchange factors and their role in autophagy signaling. The research addresses a gap in understanding how phosphoinositides regulate the DBL family of RhoGEFs, guanine nucleotide exchange factors that contain pleckstrin homology domains. The...
- The National Institute of General Medical Sciences awarded the University of Illinois $380,350 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to systematically characterize human disease-associated protein complexes. The recipient will develop machine learning approaches to identify biologically relevant protein complex variants from over 32,000 mass spectrometry experiments, construct cell-type-specific protein complex maps focusing on early embryonic...
- The National Institute of General Medical Sciences, a component of the National Institutes of Health, awarded The University of Chicago $590,711 in project grant funding on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The funding supports development of new synthetic methods to accelerate preparation of diverse analogues for medicinal chemistry studies. Over the five-year performance period ending June 30, 2031, the research addresses carbon-carbon...
The National Institute of General Medical Sciences awarded the University of Illinois $303,685 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to discover and characterize RIPP biosynthetic enzymes. The work focuses on assigning catalytic function to domains of unknown function (DUFs) encoded in microbial genomes, particularly those involved in ribosomally synthesized and posttranslationally modified peptides (RIPPs) biosynthesis. The research explores the reaction mechanisms of these enzymes and investigates their potential for engineering toward useful industrial transformations. This project addresses a key limitation in biocatalysis: the restricted repertoire of available enzymes for pharmaceutical manufacturing. By leveraging the genomic proximity of RIPP substrate genes to encoding genes for modifying enzymes, the program enables discovery of new enzymatic chemistry through co-expression strategies in suitable host organisms. Performance occurs in Urbana, Illinois, with a period of performance extending from August 1, 2026, through May 31, 2031. This is a Project Grant, a standard assistance type for investigator-initiated research at NIGMS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $303.7k | 7/30/26 |