Project Grant R35GM163632
- The National Institute of General Medical Sciences awarded $420,476 to the University of Texas Health Science Center at Houston on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support structural and mechanistic studies of eukaryotic gene transcription regulation. The recipient will conduct five years of integrated structural and molecular biology research investigating how the human CDK8 kinase module (comprising MED13, MED12, CDK8, and CYCC)...
- The National Institute of General Medical Sciences awarded Tulane University $185,511 on July 1, 2026, to support interdisciplinary training of physician scientists under the Biomedical Research and Research Training program (CFDA 93.859, Project Grant T32GM164020). The award funds the Tulane Structured Medical Training and Education for Academic Leadership (TULEAD) program, which trains Medical Scientist Training Program (MSTP) students in innovative research across infectious disease,...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded The Administrators of Tulane Educational Fund (Tulane University) $814,266 on July 1, 2026, under the Biological Sciences program (CFDA 47.074) to leverage microphysiological systems (MPS) to study molecular mechanisms of pathological angiogenesis. The project uses vessel- and tumor-on-a-chip MPS models to investigate how healthy and diseased blood vessel growth is regulated by partial...
- The National Institute of General Medical Sciences awarded the University of New Orleans $372,500 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Type: Project Grant) to investigate the role of lipid metabolism in germline-soma interactions and stress responses using Caenorhabditis elegans as a model organism. The research examines how increased germline activity—specifically in mated hermaphrodite worms compared to self-fertilized...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded Tulane University $504,681 on June 1, 2026, under the Biological Sciences program (CFDA 47.074) to develop a biophysical framework linking intramolecular energy flow to enzyme function and rational enzyme evolution. The research seeks to uncover how energy flows from solvent into proteins to enable and regulate their activity, providing a foundation for designing more efficient and versatile enzymes applicable...
- The National Institute of General Medical Sciences awarded $422,688 to the Regents of the University of California at Riverside on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing 93.859). The award funds basic research on cell signaling through the primary cilium, a microtubule-based organelle that functions as the cell's signaling hub. The research addresses how the primary cilium senses environmental signaling cues and transduces...
- The National Institute of General Medical Sciences awarded Vanderbilt University Medical Center $186,224 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate immunometabolic regulation of CD8 T cell dynamics in human critical illness and sepsis. The funded research examines how metabolic stress in critically ill and septic patients impairs CD8 T cells, which are essential for pathogen defense. Preliminary work by the investigator identified...
- The National Institute of General Medical Sciences awarded the University of Louisville $398,730 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct basic research on lipid regulation of the stem cell niche. The recipient will investigate how changes in lipid metabolism affect stem cell niche homeostasis using Drosophila melanogaster testis as a model system. The research builds on established findings that ectopic lipid accumulation in the...
- The National Institute of General Medical Sciences awarded New York University $125,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support a K99/R00 project investigating mitonuclear regulation in Caenorhabditis elegans. The research aims to determine how interactions between mitochondrial and nuclear genomes regulate gene expression and stress responses across tissues. Using natural mitochondrial variation in C. elegans combined with...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $686,308 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how microtubule- and actomyosin-based cytoskeletal networks are spatially regulated during cell division and development. The research integrates experiments in C. elegans embryos and cultured human cells, focusing on centrosomes and their role as microtubule-organizing centers. Work...
The National Institute of General Medical Sciences awarded The Administrators Of Tulane Educational Fund (Tulane University) $420,750 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the context-specific functions of the CDK8 kinase module of the Mediator complex. The research addresses how the CDK8-cyclin C complex regulates transcriptional responses to environmental and dietary cues, with specific focus on three questions: how dietary perturbation regulates the CDK8 module in Drosophila; what in vivo substrates CDK8 kinase directly targets during Drosophila development; and how CDK8 and its paralog CDK19 regulate NF-κB-dependent transcription in mammalian cells. The work builds on prior findings that CDK8-cyclin C acts as a regulatory hub linking lipid metabolism with developmental transitions and is regulated by insulin/mTOR signaling. Understanding these mechanisms is relevant to cancer and metabolic disorder pathogenesis, as CDK8 module subunits are frequently mutated or amplified in colorectal, uterine, and melanoma cancers. Performance occurs in New Orleans, Louisiana from September 1, 2026, through May 31, 2031. The award is a Project Grant, a standard assistance type under the NIGMS program supporting investigator-initiated basic biomedical research that advances understanding of biological processes and lays the foundation for disease diagnosis, treatment, and prevention advances.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $420.8k | 8/26/26 |