Project Grant R35GM163207
- The National Institute of General Medical Sciences awarded The University of Chicago $410,000 on March 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational methods enhancing causal inference in genetics and genomics over a five-year period through December 31, 2030. The research addresses confounding and generalizability barriers in Mendelian randomization and single-cell CRISPR screening by creating statistical and machine learning tools...
- The National Institute of General Medical Sciences awarded The University of Chicago $602,095 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the structure and function of molecular machines involved in protein and RNA modifications. Over the five-year performance period ending June 30, 2031, the laboratory will conduct integrated structural and biochemical studies of three interconnected systems: the ubiquitin-proteasome pathway...
- The National Institute of General Medical Sciences awarded The University of Chicago $487,525 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop evolution-based understanding and design of proteins through generative AI models and experimental validation. The work centers on deducing design principles by which high-performance, robustness, and adaptability are realized in protein evolution. The recipient will develop a generative model enabling...
- The National Institute of General Medical Sciences awarded The University of Chicago $451,000 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop statistical methods linking genetic variants to regulatory landscapes and disease mechanisms. The award funds research to move beyond cis gene regulation toward trans regulation of genes and proteins and genetic regulation of the epigenome. Specific deliverables include comprehensively mapping...
- The National Institute of General Medical Sciences awarded The University of Chicago $444,788 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate piRNA-based immunity mechanisms in germ cells across developmental and spatial dimensions. The research examines how germ cells distinguish self from non-self RNAs to protect genome integrity across generations, focusing on small RNA pathways and germ granules in C. elegans germline biology. The work...
- The National Institute of General Medical Sciences awarded $357,809 to The University of Chicago on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop sequence-based artificial intelligence frameworks for decoding genome regulation. The award funds development of three key research pillars: explainable sequence models that discover simple rules for diverse regulatory functions; novel architectures to predict long-range regulatory interactions...
- The National Institute of General Medical Sciences awarded The Regents of the University of California (UC Riverside) $420,520 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct mechanistic studies of CRISPR-Cas9 genome editing using molecular simulations and AI-driven approaches. The research integrates physics-based molecular simulations with artificial intelligence methods to advance understanding of CRISPR-Cas9 conformational dynamics,...
- The National Institute of General Medical Sciences awarded The University of Chicago $1,725,379 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing R01GM166338) to develop spatially-informed artificial intelligence tools that jointly analyze single-cell RNA-sequencing and spatial transcriptomics data to infer and quantify niche-dependent cell-state transitions in tissue contexts. The project delivers inference methods for spatial...
- The National Institute of General Medical Sciences awarded The University of Chicago $226,884 on January 18, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop multiscale computational simulations investigating actin filament branch formation and aging dynamics. The recipient will model the role of ATP hydrolysis and nucleotide state in actin-related protein (ARP) 2/3 complex subunits during branch aging and dissociation. The work focuses on mechanistic...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services, awarded the University of Illinois $526,483 on May 14, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop enhanced epigenome editing technologies for controlling mammalian gene expression. The award funds development of a toolkit of programmable epigenome editors capable of activating gene expression in vivo through three integrated aims. Aim 1...
The National Institute of General Medical Sciences awarded The University of Chicago $451,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to advance miniature CRISPR systems through directed evolution and machine learning-driven protein engineering. The award supports three integrated projects: Project 1 combines directed evolution and machine learning to reprogram the target-adjacent motif recognition of IscB, a miniature CRISPR nuclease, aiming to improve its efficiency and precision in target search and cleavage. Project 2 develops and optimizes IscB-derived base and prime editors to enable precise sequence modifications beyond standard insertions and deletions. Project 3 engineers adeno-associated viruses and virus-like particles for IscB delivery, with focus on neuron, liver, and immune cell targeting. Collectively, these efforts advance miniature CRISPR systems as versatile genome-engineering tools to overcome the delivery challenges and functional limitations of larger, commonly used CRISPR nucleases. Performance takes place in Chicago, Illinois. The period of performance runs through June 30, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $451.0k | 9/1/26 |