Project Grant R35GM162543
- The National Institute of General Medical Sciences awarded The Trustees of The University of Pennsylvania $363,875 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular mechanisms by which bacteriophages evade bacterial CRISPR-CAS immune systems. The research focuses on phage-encoded anti-CRISPR proteins, specifically ACRVA2, which inhibits the CAS12A nuclease through translation-dependent mRNA degradation. The investigator...
- The National Institute of General Medical Sciences awarded the University of Pennsylvania $406,250 on March 2, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to advance nucleic acid chemistry and synthetic biology for RNA therapeutics. The research program develops de novo xeno nucleic acids (XNAs)—synthetic nucleic acid analogs with modified backbones that enhance nuclease resistance and extend half-life—to expand the genetic toolkit for RNA silencing and...
- The National Institute of General Medical Sciences awarded The Trustees of The University of Pennsylvania $688,506 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct integrative genomic analyses of human evolution and complex traits in African populations. The research applies an integrative evolutionary genomics approach incorporating genomic, metabolomic, proteomic, microbiome, epigenomic, and transcriptomic data combined with detailed...
- The National Institute of General Medical Sciences awarded The Johns Hopkins University $388,750 on August 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct mechanistic studies of CRISPR immunity and DNA methylation through Project Grant R35GM161809. The funded work spans two research areas. The first investigates how prokaryotes acquire resistance to viruses and plasmids by integrating foreign DNA into CRISPR clusters, with the goal of understanding...
- The National Institute of General Medical Sciences awarded the University of Pennsylvania $924,095 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular mechanisms controlling actin cytoskeleton dynamics. The research addresses four major knowledge gaps: the ARP2/3 complex's role in actin filament branching and regulation by nucleotide state and binding proteins; filament dynamics at barbed and pointed ends, including cooperative...
- The National Institute of General Medical Sciences awarded The Trustees of the University of Pennsylvania $438,609 on May 7, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to fund research combining gene editing with traction force microscopy to understand mechanotransduction in leukocyte motility. The research uses CRISPR-Cas9 gene editing and traction force microscopy to conduct a directed screen of molecules implicated in cell migration, specifically...
- The National Institute of General Medical Sciences awarded $406,250 to the University of Pennsylvania on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop statistical and computational methods for analyzing complex multimodal biological datasets. The recipient will develop correlated latent factor models to extend multi-omic inference capabilities across complex study designs, including model-based imputation methods for handling missing data...
- The National Institute of General Medical Sciences awarded The Wistar Institute of Anatomy and Biology $363,191 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on the role of non-canonical nucleic acid structures in genome regulation. The funded work investigates how non-canonical DNA structures—specifically R-loops (three-stranded RNA-DNA hybrid structures formed during transcription) and G-quadruplexes (four-stranded...
- The National Institute of General Medical Sciences awarded the University of Pennsylvania $393,306 on July 7, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate cell-cell signaling mechanisms in the archaeon Haloferax volcanii. The funded research identifies quorum sensing signaling molecules and the molecular machinery that synthesizes, recognizes, and responds to these signals in archaea. The project combines forward and reverse genetics,...
- The National Institute of General Medical Sciences awarded the University of Pennsylvania $441,826 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular basis of transcription initiation at eukaryotic promoters in chromatin. The research will isolate and dissect pre-initiation complex (PIC)-mediator-coactivator complexes representing states from initiation to early elongation, using biochemical and structural approaches...
The National Institute of General Medical Sciences, part of the National Institutes of Health, awarded $345,581 to the University of Pennsylvania on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to visualize and characterize how bacteria and archaea use DNA-bending proteins to fold genomic DNA into three-dimensional shapes that regulate CRISPR-associated integrase function during adaptive immunity to phage infection. The project will employ bioinformatics, biochemistry, cryo-electron microscopy, and microbiology to elucidate how non-cas proteins facilitate DNA integration at specific genomic loci, enabling bacterial and archaeal adaptation to phage RNA and DNA. The work addresses foundational knowledge gaps in DNA-shape-mediated regulation of biological processes including DNA integration and transcription across prokaryotic and eukaryotic systems, with implications for understanding phage therapy efficacy in human microbial infections and the persistence of retroviruses such as HIV in infected patients. Performance will take place at the University of Pennsylvania in Philadelphia, Pennsylvania, from September 1, 2026, through August 31, 2031. The assistance type is Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $345.6k | 8/14/26 |