Project Grant R35GM161985
- The National Institute of General Medical Sciences awarded The Regents of the University of California, doing business as University of California, Berkeley, $246,263 in project grant funding on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research into post-transcriptional regulatory networks and the integrated stress response (ISR). The work will comprehensively characterize the cofactors engaged by regulatory RNA-binding proteins and...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, doing business as University of California, Berkeley, $617,574 on March 9, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate site-specific non-LTR retrotransposon mechanisms of mobility and transgene insertion. The research applies biochemistry, biophysical approaches, and native insertion assays to elucidate mechanisms of second-strand DNA...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, doing business as University of California, Berkeley, $387,596 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for engineering specialized organelles in yeast for compartmentalized production of therapeutics. The project re-engineers peroxisome and vacuole organelles in Saccharomyces cerevisiae as synthetic, specialized organelles for engineered...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, doing business as University of California, Berkeley, $510,183 under the Biomedical Research and Research Training program (CFDA 93.859) on March 17, 2026. The award supports the Song Lab's development of robust and scalable machine learning and statistical methods for genomics, including computational tools, statistical methods, and machine learning models for understanding evolution and...
- The National Institute of General Medical Sciences awarded the University of California, Berkeley $152,300 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct structural and biochemical investigation of how regulatory factors modulate transcription factor IID (TFIID) and its role in gene expression control. The research applies structural biology and biochemical approaches to study two distinct TFIID interactors: E proteins such as E2A, which...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, doing business as University of California, Berkeley, $441,375 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanobiology in tissue-mimetic contexts. The recipient's research addresses how cells sense, process, and respond to mechanical signals within their microenvironment, with focus on the viscoelastic properties of the...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded The Regents of the University of California, doing business as University of California, Berkeley, $1.2 million on August 1, 2026, under the Biological Sciences program (CFDA 47.074) to conduct synthetic dissection of signal-to-transcription dynamics in the Notch regulatory circuit. The research combines synthetic biology, quantitative live-cell imaging, statistical inference, and mathematical modeling to...
- The National Institute of General Medical Sciences awarded the University of California, Merced $400,910 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct computational modeling of RNA polymerase II elongation complex dynamics. The project uses molecular dynamics simulations and computational techniques including enhanced simulation methods, machine learning, and deep learning algorithms to study the elongation stage of transcription. The...
- The National Institute of General Medical Sciences awarded the University of California Santa Cruz $425,033 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to map variant histone protein interactions and elucidate the molecular mechanisms governing those interactions through advanced proteomics and structural biology. Over the five-year performance period (July 1, 2026 through April 30, 2031), the principal investigator will use nucleosome...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $526,805 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop episomal single-cell reporter assays for measuring the activity of hundreds to thousands of regulatory elements with tissue-specific resolution in whole developing embryos. The research focuses initially on enhancers as critical regulatory elements controlling gene expression timing and...
The National Institute of General Medical Sciences awarded The Regents of the University of California, doing business as University of California, Berkeley, $425,364 on August 17, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate unconventional gene regulatory mechanisms in meiosis and related cellular differentiation processes. The research focuses on how cells coordinate simultaneous activation and repression of distinct gene clusters during differentiation. The work leverages budding yeast meiosis as a model to study an unconventional regulatory mechanism centered on transcription factor-driven expression of alternative mRNA isoforms called LUTIs (long undecoded transcript isoforms) from distal gene promoters. These transcripts contain upstream open reading frames that prevent functional protein production; instead, their transcription represses canonical mRNA transcription in cis through nucleosome remodeling and chromatin modifications, enabling gene repression despite widespread transcriptional activation. A single transcription factor can thus simultaneously activate and repress protein synthesis depending on whether it binds to canonical or LUTI promoters. The mechanism is tunable and reversible, supporting dynamic gene expression changes during cell state transitions. Initial investigation into evolutionary conservation identified that the human proto-oncogene MDM2 is regulated by a LUTI. Misregulation of alternative transcription start sites appears widespread across multiple cancers, and disruption of UORF expression is linked to gonadal dysgenesis and neurodevelopmental disease, establishing potential clinical relevance. Performance occurs in Berkeley, California, with performance completion by April 30, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $425.4k | 8/17/26 |