Project Grant R35GM161984
- Federal Grant Award Summary The University of Miami received a $501,165 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective April 1, 2026, through January 31, 2031. This award supports fundamental research focused on determining the structure and dynamics of three human membrane proteins critical to physiological function and disease mechanisms: connexin channels that regulate...
- Federal Grant Award Summary The University of Florida's Division of Sponsored Research received a $680,790 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective July 1, 2025, through May 31, 2030. This award supports fundamental research to elucidate gene function through comparative genomic and experimental approaches, addressing a critical gap in the post-genomic era where approximately...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the University of Miami's Office of Research Administration within the School of Medicine a Project Grant totaling $109,076.00 under the Cancer Research Manpower program (CFDA 93.398) on December 17, 2025. The award supports biomedical research training and career development initiatives focused on cancer research through September 1, 2029. This project grant funds the institution's capacity to provide integrated...
- Federal Project Grant Award Summary The University of Miami's Office of Research Administration received a $383,750 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 1, 2026, with a completion date of February 28, 2031. This award funds fundamental biomedical research investigating sex differences in the regulation of innate immune response by neurotransmitters, specifically...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Miami $599,005 on August 21, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support a five-year research project extending through July 31, 2030. The award funds mechanistic research investigating the role of NFKBIA (IκBα) deficiency in glioma development, with particular focus on how NFKBIA...
- Federal Grant Award Summary The University of Alabama at Birmingham received a $394,434 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2030. This award funds a five-year research initiative titled "Decoding Epigenetic Adapters of Cell State," which investigates the mechanistic relationship between epigenetic modifications, cellular...
- Federal Grant Award Summary Northwestern University's Sponsored Research Division received a $440,000 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025 through May 31, 2030. This Maximizing Investigators' Research Award (MIRA) supports fundamental research investigating how the epitranscriptome—the collection of chemical modifications on RNA molecules—regulates...
- Federal Grant Award Summary Florida International University received a $405,625 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) for research titled "Functional Dynamics and Interactions of CYP19." The award, effective April 1, 2026 through January 31, 2031, supports fundamental basic research into cytochrome P450 (CYP) enzymes, with specific focus on aromatase (CYP19) as a model...
- Federal Grant Award Summary The University of Florida's Division of Sponsored Research received a $383,750 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective April 1, 2026, through January 31, 2031. This award supports fundamental research investigating post-translational modifications (PTMs) in archaea, specifically examining how PTM systems—including ubiquitin-like proteasome systems...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The University of Texas Health Science Center at San Antonio a $378,000 Project Grant effective May 1, 2026, through April 30, 2031, under the Biomedical Research and Research Training program (CFDA 93.859). This five-year project funds fundamental research investigating how intrinsically disordered proteins and intrinsically disordered regions regulate critical nuclear processes including...
The University of Miami's Office of Research Administration—School of Medicine received a $318,084 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective May 15, 2026, with a completion date of February 28, 2031. This award consolidates two prior R01 grants into a MIRA-R35 (Maximizing Investigators' Research Award) mechanism focused on non-canonical functions of polycomb complexes in health and disease. The research investigates epigenetic mechanisms through multiple work streams, including examination of the E3-ligase RING1B's role in regulating oncogenic pathways in breast cancer and the remodeling of the epigenome and genome instability related to loss of H3K36ME3 and polycomb repressive complexes (PRC1/PRC2) in head and neck squamous cell carcinoma (HNSCC). The research program employs diverse model systems and methodologies—including breast and HNSCC cellular models, knock-in and knock-out cell lines, patient-derived organoids, xenografts, orthotopic xenograft models, and biochemical and mass spectrometry assays—to generate novel insights into deregulated epigenetic mechanisms in cancer and neurodevelopmental disorders. The work aims to identify RING1A's role in gene regulation and therapeutic resistance, characterize non-histone substrates of RING1A and RING1B, and investigate de novo missense mutations in PRC1 genes that drive neurodevelopmental disorders, ultimately supporting development of targeted therapeutic strategies and anti-epigenetic compound combinations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $318.1k | 5/14/26 |