Project Grant R35GM161701
- The National Institute of General Medical Sciences awarded The University of Texas Health Science Center at San Antonio $433,125 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research into the spatiotemporal regulation of DNA metabolism pathways. The project examines how homologous recombination proteins are selectively activated and deactivated at DNA lesions and replication fork structures, with particular focus on tyrosine...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded the University of Texas Health Science Center at San Antonio $433,976 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular mechanisms of BRCA1/2-mediated genome stability maintenance. The funded research addresses homologous recombination pathways and DNA double-strand break repair in...
- The National Institute of General Medical Sciences awarded the University of Texas at Austin $491,703 in Project Grant funding on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on the molecular mechanisms of cohesin-mediated three-dimensional genome organization. The recipient will conduct mechanistic studies of how the cohesin complex, the architectural protein CTCF, its unloading factor WAPL, and regulatory RNAs collaborate to...
- The National Institute of General Medical Sciences awarded the University of Texas at Austin $771,265 on September 15, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct structural and functional imaging of macromolecular machines involved in gene regulation using cryo-electron microscopy. The research encompasses three principal investigative avenues: mechanisms of RNA-guided CRISPR-Cas surveillance, methods to determine structures of human protein...
- The National Institute of General Medical Sciences (NIGMS), part of the Department of Health and Human Services National Institutes of Health, awarded the University of Texas at Dallas $435,875 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing) to investigate how tissue-specific progenitor cell fate is governed by mesenchymal progenitors and sympathetic neurons during adult tissue regeneration. The recipient will use the postnatal mouse...
- The National Institute of General Medical Sciences (NIGMS), through its Biomedical Research and Research Training program (CFDA 93.859), awarded a $355,584 Project Grant to the New Mexico Institute of Mining and Technology (New Mexico Tech) on August 18, 2023. This funding will support research to determine the biochemical basis and functional implications of the interaction between the proteins XRN2 and DDX23, and explore their cooperative role in regulating RNA-DNA hybrid structures...
- The National Institute of General Medical Sciences, part of the National Institutes of Health within the Department of Health and Human Services, awarded The University of Texas Southwestern Medical Center $488,525 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859), a Project Grant (R35GM162011). The award funds evolution-guided studies of mitochondrial activities and the host response to infectious agents. The research characterizes newly identified...
- The National Institute of General Medical Sciences awarded University of Texas at Austin $434,480 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to elucidate the mechanisms of mitochondrial DNA heteroplasmy quality control. The project investigates how mitochondrial genomes maintain fidelity when both wild-type and mutant mtDNA coexist (heteroplasmy), and how tissue-specific thresholds govern mitochondrial function. The research leverages...
- The National Institute of General Medical Sciences awarded The University of Texas Health Science Center at San Antonio $378,000 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how intrinsically disordered proteins and regions regulate nuclear processes essential for genome stability, including transcription, RNA processing, and the DNA damage response. Over five years through April 30, 2031, the recipient will identify sequence and...
- The National Institute of General Medical Sciences awarded the University of Texas at Austin $429,650 on April 6, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the interplay between cellular metabolism, chromatin regulation, and transcriptional control in ethylene signaling and stress responses in Arabidopsis. The research explores how chromatin-modifying enzymes utilize metabolic cofactors to influence histone modifications, nucleosome structure,...
The National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health within the Department of Health and Human Services, awarded the University of Texas at Austin $485,765 on August 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for a Project Grant (R35GM161701) investigating the interactions between homologous recombination and non-homologous end joining pathways in double-strand break repair in human cells. The research examines whether these two DNA repair pathways operate competitively or collaboratively, challenging the historical view that they function independently. The work focuses on how non-homologous end joining factors regulate initiation of homologous recombination through interactions between the MRE11-RAD50-NBS1 complex and NHEJ machinery, including investigation of phosphorylation-mediated protein recruitment and mechanistic structures. The project also investigates how NHEJ factors recognize breaks during DNA replication and dysregulation mechanisms relevant to cancer predisposition and neurological disease. Work is performed at the University of Texas at Austin in Austin, Texas. The award runs through March 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $485.8k | 8/12/26 |