Project Grant R35GM161430
- Federal Project Grant Award Summary Emory University received a $2,021,315 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2029. The award supports a five-year research initiative focused on developing vanadium-dependent haloperoxidase (VHPO) enzymes for novel applications in chemical synthesis. The research addresses a critical gap in...
- The National Institute of General Medical Sciences awarded Emory University $430,375 in a Project Grant (Assistance Listing 93.859, Biomedical Research and Research Training) on August 1, 2026, to support systematic studies of natural glycans and their interactomes through innovative methodologies for protein-glycan interaction research. The work develops and applies advanced chemistry tools—including the Oxidative Release of Natural Glycans (ORNG) method and DNA-encoded glycan libraries as...
- The National Institute of General Medical Sciences awarded Georgia TECH Research Corp $432,850 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct computational research on protein dynamics and allostery in biomedically important enzymes. The work uses biomolecular simulations to explore conformational dynamics, allosteric regulation, and catalytic function in three enzyme systems: PRIA and TRPC (central to tryptophan biosynthesis and potential...
- The National Institute of General Medical Sciences awarded Emory University $423,357 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a scalable, causality-aware foundational topic modeling framework for single-cell multi-omics data. The project addresses critical limitations in existing representation learning methods for high-dimensional single-cell multi-omics datasets by developing interpretable topic representations enriched in causal...
- The National Institute of Biomedical Imaging and Bioengineering awarded Emory University $217,443 on August 5, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop class-selective chemical probes that distinguish reactive aldehyde signaling in living systems. The research will create a sensing platform capable of discriminating four mechanistically distinct classes of reactive aldehydes—monoaldehydes, α-dicarbonyls,...
- The National Institute of General Medical Sciences awarded Duke University $737,152 on March 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to elucidate the mechanisms and functions of metalloenzymes in cofactor and natural product biosynthesis. The research focuses on structural and mechanistic characterization of two enzyme families: radical S-adenosyl-L-methionine (RSAM) enzymes that catalyze oxygen-independent radical-mediated reactions, and non-heme...
- The National Institute of General Medical Sciences awarded Emory University $430,375 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the role of dietary phytochelatins in human metal homeostasis. The research examines how phytochelatins—thiol-containing peptides present in plants and ubiquitous in human diets—regulate the balance between essential trace metal availability and toxic heavy metal accumulation. The project uses molecular and...
- Emory University was awarded a $450,000 project grant from the National Science Foundation Division of Chemistry to support research investigating the mechanisms of hydrogenase function. The three-year award, made under the Mathematical and Physical Sciences program (CFDA 47.049), will allow Emory researchers to advance understanding of major problems in the natural sciences through increasing knowledge of how the hydrogenase enzyme catalyzes reactions involving hydrogen. Work will be...
- The National Institute of General Medical Sciences awarded Duke University $482,750 on May 1, 2026, to develop computational methods for in-situ structure determination using cryo-electron tomography (cryo-ET) under the Biomedical Research and Research Training program (CFDA 93.859). The project addresses bottlenecks in single-particle cryo-ET workflows to broaden applicability and improve access to the technology for structural biologists. Current cryo-ET analysis is largely confined to...
- The National Institutes of Health Office of the Director awarded Emory University $1.7 million on May 18, 2026, under the Research Infrastructure Programs (CFDA 93.351) to acquire a Bruker timsTOF Ultra-2 mass spectrometry system coupled with an Evosep LC for the Emory Glycomics and Molecular Interactions Core (EGMIC). The system will deliver ultra-sensitive proteomics and glycomics analytical capabilities for NIH-funded research requiring analysis of proteins, lipids, and glycans from extremely...
The National Institute of General Medical Sciences awarded Emory University $378,194 on August 1, 2026, as a Project Grant to characterize enzyme dynamics in radical catalysis under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research into the role of protein and solvent motions in enzyme function, using time-resolved and static electron paramagnetic resonance spectroscopy to isolate intermediate states and chemical reaction steps in the B12-dependent enzyme ethanolamine ammonia-lyase. The research develops low-temperature experimental systems, custom instrumentation, analysis software, and innovative methods employing electron spin probes and trap reporters to correlate enzyme reactivity with independently-measured protein dynamics, testing the hypothesis that thermally-driven stochastic motions of active site groups constitute a critical choreography within reaction chemistry. Emory University's Office of Sponsored Programs is the recipient. Performance occurs in Atlanta, Georgia, with a period of performance extending from August 1, 2026, through March 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $378.2k | 7/30/26 |