Project Grant R35GM160566
- This Project Grant award of $423,500.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research at the University of Utah to uncover fundamental cell signaling mechanisms that can be therapeutically targeted in disease. The award, with a performance period from July 1, 2025 to June 30, 2030, focuses on two key projects: Addressing the regulation and function of kinases in the "dark...
- The Project Grant award of $528,000.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research to reveal the molecular basis of microtubule-intermediate filament interactions. The research will focus on understanding how microtubules and neurofilaments, which are key cytoskeletal components in myelinated axons, are adapted to form specialized cytoskeletal arrays that regulate cell shape and...
- This federal Project Grant award, valued at $427,625.00 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research on the conformational dynamics and regulatory mechanisms of the KCNH family of ion channels. The research aims to examine the voltage sensor domain and S4 helix of KCNH channels to measure their structural changes during channel opening and closing. The project will...
- This $228,340 federal Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research to investigate the role of endoplasmic reticulum (ER)-to-actin tethering in cell migration, a critical process for tissue development and repair. The research aims to determine the mechanisms by which the ER interacts with the actin cytoskeleton and spatially coordinates ER-actin...
- This federal Project Grant award of $584,420 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the "Spatiotemporal Mapping and Engineering in the Dark Proteome" research project at the Albert Einstein College of Medicine. The research aims to investigate how protein motions associated with intrinsic disorder contribute to specific biological functions, utilizing methods such as NMR,...
- This federal Project Grant award of $621,546.00, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), focuses on observing the single molecule dynamics of the catalytic subunit of cAMP-dependent protein kinase A (PKA-C) under both normal and disease-associated conditions. The primary objectives are to: 1) Engineer a single-walled carbon nanotube field effect transistor (SWNT FET) system to record PKA-C single molecule...
- This $414,159 Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand the differential stress responses of organelles in eukaryotic cells. The research aims to investigate the molecular mechanisms underlying how cells employ different strategies to respond to nutritional deprivation versus endoplasmic reticulum (ER) stress. The principal investigator at the...
- This federal Project Grant award of $534,160.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program to investigate the molecular mechanisms underlying proteins and protein complexes that facilitate intracellular ion transport and ensure genomic integrity. The research aims to elucidate the mechanisms by which ions are recognized and transported across membranes, how the...
- This federal Project Grant award of $452,192.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of pan- and phospho-specific nanobodies for investigating MAPK and PP2A signaling. The award to Vanderbilt University, effective June 1, 2025, aims to further the fundamental scientific understanding of protein phosphorylation, an essential cellular process, through the creation of...
- This Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (CFDA 93.853), supports research to understand how G protein-coupled receptors (GPCRs) regulate cellular functions in cardiomyocytes and neurons. The $396,031 award to the Augusta University Research Institute, Inc. will map the subcellular distribution of heterotrimeric G proteins, investigate how G proteins move upon receptor activation, and determine if G proteins are concentrated at specific...
This Project Grant award, valued at $423,500.00 and issued on August 5, 2025, supports research conducted by the University of Utah under the Biomedical Research and Research Training program (CFDA 93.859) administered by the National Institute of General Medical Sciences (NIGMS). The research aims to investigate the regulatory mechanisms governing the organization of endoplasmic reticulum-plasma membrane junctions in mammalian neurons, with a focus on cAMP-dependent protein kinase (PKA) signaling. Specifically, the project will define the signaling interactions at PKA-containing ER-PM junctions, map enzyme substrates targeted to these sites, and examine how AKAP-enzyme signaling complexes are structurally organized. This research is expected to provide critical insights into how electrical signals are translated into intracellular biochemical responses, including the activation of gene expression programs, with potential implications for understanding neurological processes and disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $423.5k | 8/1/25 |