Project Grant R35GM160530
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $418,750.00 to The Feinstein Institutes for Medical Research to conduct research on T cell receptor-mediated T cell activation in neonatal and pediatric sepsis. The goal is to gain insight into how T cell memory influences sepsis-associated organ dysfunction, by comparing responses between human neonates with sepsis and...
- This federal Project Grant award of $423,500.00, provided by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program, aims to address two critical challenges related to burn sepsis: Identifying distinct immune response phenotypes after burn injury and their relation to sepsis development, in order to enable novel approaches to mitigate sepsis risk. Determining the mechanism by which elevated angiopoietin-2 (ANGPT-2) leads...
- The Research Foundation for the State University of New York received a $108,512 Project Grant from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) to develop novel immune-modulating itaconate-loaded telodendrimer nanoparticles to target both hyperinflammation and pyroptosis in sepsis. The project aims to address the current gap in therapies that can directly mitigate excessive cytokine production and immune cell pyroptosis,...
- This federal Project Grant award of $422,125 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to assess whether multi-omic data of myeloid-derived suppressor cells (MDSCs) can improve sepsis endotyping and predict clinical trajectories in chronic critical illness (CCI) after sepsis. The overarching goal is to better understand the role of "pathologic myelopoiesis" and MDSC...
- The University of Rochester received a $462,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to study how the human microbiome regulates neutrophil responses in sepsis. The research aims to determine if differential priming of the immune system by healthy blood microbiomes predisposes patients to heterogeneous responses to sepsis. Preliminary evidence suggests that microbiome-mediated training of...
- This Project Grant award of $455,000 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to decrease sepsis mortality in the pediatric population. The key products and services to be delivered include: Developing an AI-guided early sepsis identification tool to enable timely diagnosis and treatment. Performing sepsis phenotyping and creating digital twin patient models to predict personalized treatment responses....
- This Project Grant award of $403,750 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to unravel the relationships between gut microbial signatures, blood microbial signatures, and immune responses in sepsis patients. The research will integrate gut microbial community profiling, metabolomics, intestinal permeability measures, and blood microbial signatures with immune phenotypes and clinical...
- This Project Grant award, in the amount of $187,410, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant will support Dr. Hilary Faust, an early-career physician-scientist, in developing novel approaches to identify and target sepsis-associated endothelial dysfunction. The funding will enable Dr. Faust to master advanced techniques for modeling human sepsis-associated endothelial injury...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $179,475 to The Children's Hospital of Philadelphia (CHOP) to conduct research on pediatric sepsis. The key objectives of the project are to define and validate a molecular subphenotyping model that can predict the severity of sepsis in children, and to test the reversibility of immune dysregulation through targeting...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $132,677 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Icahn School of Medicine at Mount Sinai (ISMMS) to conduct research on mapping genetic variants associated with inflammatory bowel disease (IBD) to their target genes and functional effects in human macrophages. The project aims to elucidate the transcriptional consequences of IBD candidate genes in monocytes and...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $462,981.00 to the Icahn School of Medicine at Mount Sinai to conduct research aimed at gaining a holistic understanding of the complex factors contributing to sepsis pathogenesis. The overarching goal is to determine how genetic factors work with clinical, behavioral, and social determinants of health to shape sepsis risk and outcomes, and to uncover the biological mechanisms that connect genetic variants to sepsis risk. The research will leverage large and ancestrally diverse electronic health record-linked biobanks to define sepsis case-control status, run genetic association tests, and discover novel sepsis risk variants. The research will also stratify cases and controls by comorbidity and account for the potential confounding effect of behavioral and social determinants of health on sepsis outcomes. The award has an end date of July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $463.0k | 8/12/25 |