Project Grant R35GM160372
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), has awarded a $384,722 Project Grant to Emory University to develop statistical approaches for integrating multi-view, multi-section, and multi-sample spatial transcriptomics data to decipher disease mechanisms. The project aims to provide researchers with analytical tools to tackle challenges in population-scale spatial transcriptomics data analysis, beginning...
- The U.S. Department of Health and Human Services, National Institute of General Medical Sciences (NIGMS) awarded a $449,625 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Trustees of Boston University. The grant, awarded on September 15, 2025, supports research to develop new experimental strategies and computational approaches for studying single-cell gene expression trajectories. The overarching goal is to enable foundational advances in...
- The National Institute of General Medical Sciences (NIGMS) awarded a $349,243 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Imagen Bioworks Inc. on September 12, 2025. The grant supports the development of an innovative "Spotlight-Omics" workflow that can cost-effectively isolate disease-relevant spatiotemporal phenotypes from live cell cultures for subsequent omics analysis. This workflow aims to address a critical limitation of current...
- The National Institute of General Medical Sciences (NIGMS) has awarded a $536,250 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Sanford Burnham Prebys Medical Discovery Institute (SBP). The project aims to develop computational methods that can analyze single-cell transcriptomic data to better identify and study rare cell populations, such as tissue stem cells, senescent cells, and tumor-initiating cells. The approach will use...
- This federal Project Grant award of $436,001 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to create a novel spatial transcriptomics platform that increases accessibility and efficiency. The key products and services to be delivered include: Developing a spatial transcriptomics platform using a simple filter array format that increases sequencing depth per spatial barcode, enabling more data per...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $431,656 Project Grant to the University of Massachusetts to elucidate the function of ribonucleoprotein (RNP) condensates in living cells. The research aims to develop novel methods to accurately identify the RNA-binding proteins that regulate the formation and disassembly of RNP condensates, which play a crucial role in cellular function and disease...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $306,700 Project Grant to Rybodyn, Inc. for the development of a novel spatial biology platform for cost-effective and scalable protein profiling. The goal of this 12-month project is to create a non-destructive, image-free spatial biology platform that can achieve sub-cellular resolution of protein presence and abundance using proprietary barcoded tags...
- This federal Project Grant award of $393,093, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project titled "Uncovering Spatio-Temporal, Mechano-Transcriptomic Signatures of Development". The principal investigator is Bianca Dumitrascu. The goal of this 5-year project is to understand the interplay between gene expression, cell morphology, and tissue-level mechanics in...
- This federal Project Grant award of $460,740 from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 (Biomedical Research and Research Training program) will support research by Yale University to develop scalable methods for inferring the most important interactions within large biological networks. The goal is to investigate two model systems: (i) neural activity and (ii) chromatin structure, in order to identify the networks of interactions that best describe...
- The National Institute of General Medical Sciences (NIGMS) awarded a $333,048 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Imagen Bioworks Inc. in Houston, TX. The goal of this 1-year project is to develop a versatile 2-photon microscopy platform, dubbed 2P-SPOTLIGHT, to isolate individual cells from 3D tissue samples and 3D cell cultures based on their spatial and temporal properties. This will enable researchers to conduct downstream multi-omics...
The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $423,616 Project Grant to Brown University. The grant, effective from September 1, 2025 to June 30, 2030, will support the development of integrative computational models to decode disease mechanisms and predict drug synergies in spatial transcriptomics. The research aims to uncover how the spatial arrangement of cells within tissues (cellular spatial organization) influences disease progression and treatment efficacy, particularly in complex conditions like cancer, neurodegenerative diseases, and inflammatory disorders. The project will: (1) integrate spatial transcriptomics data with bulk RNA-sequencing and clinical phenotypes to identify cellular spatial patterns associated with key outcomes, including survival and therapeutic response; and (2) design a deep learning framework that combines spatial transcriptomics with pharmacogenomic and drug chemical data to predict how spatial heterogeneity affects drug responses.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $423.6k | 8/28/25 |