Project Grant R35GM160331
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop new chemical strategies for controlling the conformation of bioactive peptides and proteins. The $385,671 award, effective from September 1, 2025 to August 31, 2030, aims to synthesize and evaluate novel amino acid analogs that can influence the secondary structures of peptides and proteins, with the goal...
- This federal Project Grant award of $329,976 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to establish a multiscale modeling strategy to simulate ion selectivity in proteins. The principal investigator will utilize novel force fields to conduct molecular dynamics simulations that provide structural, dynamic, and thermodynamic insights into protein-ion interactions. The research aims to analyze the...
- This federal Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of new reagents and methods for synthesizing oligophosphate constructs - phosphorylated biomolecules that play essential roles in human physiology and health. The $444,262 award, effective June 1, 2025 through March 31, 2030, will enable the Massachusetts Institute of Technology (MIT) to: Develop...
- This Project Grant award of $638,334 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to advance the understanding of structural mechanisms underlying protein-small molecule binding and protein function. The project will develop novel computational methods for thermodynamic mapping of proteins, ligands, and surrounding aqueous solvent using molecular dynamics simulations. The goal is to create a...
- This federal Project Grant award of $584,420 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the "Spatiotemporal Mapping and Engineering in the Dark Proteome" research project at the Albert Einstein College of Medicine. The research aims to investigate how protein motions associated with intrinsic disorder contribute to specific biological functions, utilizing methods such as NMR,...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund a $540,000 research project at Northwestern University to measure the global folding stability and folding energy landscapes for 3 million protein sequences. The project aims to create a large dataset quantifying these properties, which have historically been challenging to investigate at scale. This data will empower...
- The National Institute of General Medical Sciences (NIGMS) awarded a $2,503,299.00 Project Grant under CFDA 93.859 - Biomedical Research and Research Training to St. Jude Children's Research Hospital Inc. The grant, titled "Developing and Discovering Covalent Inhibitors through Fragmentation-First Experimentation", aims to leverage a novel chemical framework to dramatically simplify access to small molecules and accelerate the processes for studying their interactions with...
- This federal Project Grant award of $524,400.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding supports research at the Scripps Research Institute in La Jolla, CA to develop novel chemical transformations and catalysts that enable the efficient synthesis of structurally complex small molecules for drug discovery. The research aims to address challenges in organic synthesis by...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $455,940 to the University of Massachusetts Lowell to study the biophysical properties of intrinsically disordered proteins (IDPs) when confined to nanoscale environments. The research aims to reveal how the structural plasticity of IDPs is influenced by their localization and confinement on nanoparticle constructs, with the...
- This Project Grant award, valued at $400,178.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Nevada, Reno. The award, effective August 8, 2025, aims to enhance the protein engineering and design toolbox by exploring the relationships between protein sequence, structure, and function in multifunctional proteins. The research will focus on engineering designer protein...
This Project Grant award, totaling $387,857.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a research project titled "A Molecular Recognition Guidebook for Targeting Protein Loops with Covalent Ligands" at the University of Notre Dame DU Lac. The project aims to elucidate the structural and biophysical principles governing the interactions between small molecule covalent ligands and protein loop structures, with a focus on RNA recognition motif (RRM) domains. The research seeks to develop a systematic understanding of how ligand shape, feature diversity, and loop motion influence covalent bond formation and modulation of protein function. The award period runs from September 1, 2025, to August 31, 2030, and the findings are expected to provide a framework for targeting protein loops with covalent ligands in drug discovery efforts.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $387.9k | 8/11/25 |