Project Grant R35GM160285
- The National Institute of General Medical Sciences (NIGMS) awarded a $365,616 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Gettysburg College, a private non-profit educational institution in Pennsylvania. The funding will support the development of a library of triazine-based, ionizable lipids that can be used to form lipid nanoparticles (LNPs) for delivering RNA into cells. The project aims to establish a structure-activity relationship (SAR)...
- The National Institute of General Medical Sciences (NIGMS), through the Biomedical Research and Research Training program (CFDA 93.859), awarded a $963,619 Project Grant to Osem Fluidics Inc. on January 1, 2025. The award supports the development of 3D-printed microfluidic channel architectures to precisely control the structure and properties of lipid nanoparticles (LNPs) for enhanced nucleic acid delivery. Key objectives include designing and testing 3D channel designs to manipulate flow...
- The federal Project Grant award, totaling $448,250.00, was granted by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to support the development of sulfonium lipid nanoparticles (SLNPs) as a novel platform for mRNA delivery. The primary objective is to expand the chemical diversity of sulfonium lipids, investigate their unique physicochemical and biological properties, and explore the therapeutic potential of...
- This $147,091 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project on plasmonic nanoantenna-enhanced fluorescence immunoassay enabled by super-hydrophobic surfaces. The goal is to develop a transformative fluorescence detection technology that can achieve ultra-low and ultra-sensitive protein detection, which is crucial for early disease diagnosis. The project...
- This federal Project Grant award of $465,197 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a next-generation lipidomics platform using advanced mass spectrometry and bioinformatics technologies. The goal is to enable high-throughput lipidomic profiling with high structural specificity to unravel the relationship between lipids and their associated functions in biological...
- This federal Project Grant award, valued at $375,337.00 and provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports the development of photothermal mid-infrared single molecule super-localization microscopy to track the intracellular processes governing mRNA release from lipid nanoparticle (LNP) formulations. The goal is to provide...
- The National Institute of General Medical Sciences (NIGMS) awarded a $218,622 Project Grant to Vitan-Biotech LLC on September 22, 2023 under the Biomedical Research and Research Training program (CFDA 93.859). The grant will fund the development of an integrated pipeline to rapidly discover and characterize selective, high-affinity nanobodies against defined G protein-coupled receptors (GPCRs) that are important for neurological disorders like schizophrenia, pain, Parkinson's, Alzheimer's, and...
- The National Institute of General Medical Sciences (NIGMS) awarded a $385,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Leland Stanford Junior University (Stanford University) to identify and characterize novel lipid transport and processing proteins in Plasmodium, the parasite that causes malaria. The goal is to understand the range of lipids transported by Plasmodium and how its independently evolved lipid transport and processing...
- This $381,995 federal Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program. The grant supports research to investigate and manipulate cells in low oxygen environments using lipid nanoparticles. Specifically, the research will focus on two areas: 1) Conducting comparative analyses to understand how low oxygen environments impact the cellular uptake mechanisms of mRNA lipid...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) aims to characterize the mechanisms by which lipid nanoparticle (LNP) formulations induce immune responses, with the goal of enhancing LNP-based anti-tumor therapies. The $128,736 award to the Icahn School of Medicine at Mount Sinai will be used over a 2.5 year period from Dec 2024 to Jul 2027 to investigate how LNP properties and targeting influence their interactions with dendritic...
The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $375,633 project grant to the University of Nevada, Las Vegas (UNLV) to develop an enhanced lipid nanoparticle (LNP) platform for selective and improved delivery of therapeutics in vivo. The key objectives are to: 1) investigate how LNP interactions with endogenous systems can be leveraged to redesign and improve delivery systems; and 2) examine how incorporating endogenous ligands impacts LNP properties such as encapsulation efficiency, endosomal escape, protein expression, and immunomodulation. The research program aims to bridge the knowledge gap on how surface decoration with endogenous ligands affects LNP performance, with a focus on targeting the pancreas and immune system. This 5-year project grant, awarded on Aug 7, 2025, supports fundamental research to advance the development of more effective next-generation LNP systems as advanced therapeutics.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $375.6k | 8/6/25 |