Project Grant R35GM160152
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $272,596 to the University of Arizona to conduct research on how chaperone proteins assist in protein folding and prevent toxic protein aggregation. The research aims to address four key questions: 1) how ATP induces conformational changes in the subunits of the Hsp60 chaperone, 2) how substrates interact with...
- This Project Grant award of $638,334 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to advance the understanding of structural mechanisms underlying protein-small molecule binding and protein function. The project will develop novel computational methods for thermodynamic mapping of proteins, ligands, and surrounding aqueous solvent using molecular dynamics simulations. The goal is to create a...
- The University of Southern California received a $342,342 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) for their project titled "CHEMISTRY-ENABLED GLYCOSCIENCE." The project aims to develop and apply chemistry-enabled approaches to address unresolved questions in the field of glycoscience, which studies the role of glycans (complex carbohydrates) in biological processes and...
- This federal Project Grant award of $584,420 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the "Spatiotemporal Mapping and Engineering in the Dark Proteome" research project at the Albert Einstein College of Medicine. The research aims to investigate how protein motions associated with intrinsic disorder contribute to specific biological functions, utilizing methods such as NMR,...
- The National Institute of General Medical Sciences (NIGMS) awarded a $384,527 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, Irvine (UCI) for the project "Deciphering the Interactome and Functions of Disordered Microproteins." The 5-year project aims to leverage the unique biochemical properties of microproteins, a recently discovered class of small proteins, to identify their interactions and functions across...
- This $440,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program to investigate the ubiquitin and autophagy pathways, which are essential cellular processes involved in proteostasis or protein homeostasis. The research team at the Sloan-Kettering Institute for Cancer Research aims to uncover novel regulatory mechanisms within the ubiquitin system and enhance...
- This Project Grant award for $185,000.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a research project at the University of North Florida to examine the role of J-domain protein interactions with the molecular chaperone HSP70 and their impact on protein folding and misfolding processes. The research aims to further the understanding of how J-domain protein/HSP70 systems...
- This Project Grant award of $501,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research by The Regents of the University of California, San Francisco (UCSF) to develop simulation-based models that can more accurately interpret experimental data in structural biology. The goal is to enhance understanding of how macromolecules communicate and interact, which is vital for advancing...
- This $153,488 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate the mechanisms by which the HSP70 molecular chaperone system interacts with the AAA+ disaggregase HSP104 to target and solubilize toxic amyloid aggregates. The research aims to use biochemical and cryo-EM structural approaches to define the precise interaction between HSP70 and HSP104, and how this...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund a $540,000 research project at Northwestern University to measure the global folding stability and folding energy landscapes for 3 million protein sequences. The project aims to create a large dataset quantifying these properties, which have historically been challenging to investigate at scale. This data will empower...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $2,282,500 to the University of Southern California (USC) to deepen the understanding of the molecules and mechanisms that drive protein aggregation. The research aims to explore the biological implications of disaggregases, which are enzymes that can both catalyze and inhibit protein aggregation, and how they may reversibly regulate protein function. Key objectives include bioinformatic, biochemical, and cellular studies to uncover the molecular determinants of disaggregase activity and identify new biological disaggregases in the human metabolome. The project will run from September 1, 2025 through August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.3m | 8/4/25 |