Project Grant R35GM160133
- This federal Project Grant award, valued at $427,625.00 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research on the conformational dynamics and regulatory mechanisms of the KCNH family of ion channels. The research aims to examine the voltage sensor domain and S4 helix of KCNH channels to measure their structural changes during channel opening and closing. The project will...
- This $576,104 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports fundamental research on the molecular mechanisms underlying transmembrane conduction and signaling in integral membrane proteins. The research aims to define the structural transitions and energy coupling processes that drive and regulate cyclical processes in membrane proteins, with a focus on understanding voltage...
- This $630,414 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (CFDA 93.853) supports research at Northwestern University to investigate the role of sodium channel dysfunction in altered brain development. The research aims to phenotype the prenatal and postnatal impacts of pathogenic variants in the SCN2A and SCN3A sodium channel subtypes, using a ferret model system to study the biological basis of related neurological disorders. The award,...
- This $382,436 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the mechanisms regulating the synthesis, sorting, trafficking, and release of neuropeptides from dense core vesicles within neurons. The project aims to create new transgenic fly lines to directly visualize these intracellular processes in vivo using advanced microscopy techniques. Key...
- This $496,200 federal Project Grant awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences program (CFDA 47.049) supports research led by Professor Li at the University of Mississippi. The project aims to use advanced computational modeling to investigate the critical role of glycosylation in regulating ion channel function, which is essential for numerous physiological processes. The research seeks to elucidate the atomic-level interactions between glycans...
- This federal Project Grant award of $329,976 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to establish a multiscale modeling strategy to simulate ion selectivity in proteins. The principal investigator will utilize novel force fields to conduct molecular dynamics simulations that provide structural, dynamic, and thermodynamic insights into protein-ion interactions. The research aims to analyze the...
- This Project Grant award of $638,334 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to advance the understanding of structural mechanisms underlying protein-small molecule binding and protein function. The project will develop novel computational methods for thermodynamic mapping of proteins, ligands, and surrounding aqueous solvent using molecular dynamics simulations. The goal is to create a...
- This Project Grant award of $501,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research by The Regents of the University of California, San Francisco (UCSF) to develop simulation-based models that can more accurately interpret experimental data in structural biology. The goal is to enhance understanding of how macromolecules communicate and interact, which is vital for advancing...
- This Project Grant award of $104,298 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will fund research to delineate the activity, gating mechanism, and potential pharmacological interventions of two pathological GRIN1 variants at residue 647 (Y647C and Y647S). Patients with these variants exhibit severe cognitive developmental delay, acquired microcephaly, bilateral...
- This National Science Foundation Project Grant under the Integrative Activities program (CFDA 47.083) provides $193,620 to the University of Delaware from February 1, 2023 to January 31, 2025. The funding will support research using computational and experimental ultrafast vibrational spectroscopy to unravel the gating mechanisms of ion channels. Specifically, the awardee will combine molecular dynamics simulations with computational spectroscopy to study activation mechanisms of potassium...
This federal Project Grant award, valued at $383,008, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The purpose of the grant is to conduct computational studies on the molecular mechanisms underlying various mutations in voltage-gated sodium (NaV) channels, which are associated with a broad spectrum of channelopathies including epilepsy, autism, and cardiac arrhythmias. The research aims to gain a better understanding of how specific NaV channel mutations can lead to variable or even opposing functional effects, in order to inform the development of mutation-specific therapeutics for precision medicine. The University of Mississippi, the awardee, will utilize molecular dynamics simulations and conformational free-energy calculations to investigate the structural and dynamic impacts of representative NaV channel mutations within a practical simulation timeframe. This work is intended to provide mechanistic insights that can aid the design of targeted therapies for NaV channel-related disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $383.0k | 8/14/25 |