Project Grant R35GM159998
- This federal Project Grant award of $422,125 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to assess whether multi-omic data of myeloid-derived suppressor cells (MDSCs) can improve sepsis endotyping and predict clinical trajectories in chronic critical illness (CCI) after sepsis. The overarching goal is to better understand the role of "pathologic myelopoiesis" and MDSC...
- The University of Florida was awarded a $466,125 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant, awarded on August 1, 2025, will fund research to "DECODING RNA LOCALIZATION AND LOCAL TRANSLATION: KEY MECHANISMS OF CELLULAR ADAPTION AND FUNCTION". The project aims to use advanced imaging and proximity labeling approaches, both in vivo and in vitro, to illuminate how...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $447,337 to Ball State University to conduct research on the regulator MITONEET and its role in cellular redox homeostasis and signaling. The research aims to investigate how the electronic properties and stability of the MITONEET [2Fe-2S] cluster contribute to the metabolism of sulfur-containing molecules and the...
- This federal Project Grant award for $647,301 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to advance the understanding of iron-sulfur enzymes. The key objectives are to: Develop synthetic models of iron-sulfur enzyme active sites to characterize their molecular-level structures and reaction mechanisms, and Improve spectroscopic methods for analyzing the complex iron-sulfur clusters...
- This Project Grant award, valued at $379,394.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a research project investigating the mechanisms by which human cells detect and respond to oxidative stress, with a focus on understanding the dose-dependent activation of key stress response proteins. The research aims to uncover how dynamic stress response pathways influence cell...
- This Project Grant award of $680,790.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research led by the University of Florida to elucidate the function of unknown genes and identify missing enzymes involved in tRNA and DNA modifications. Specifically, the research aims to discover the transporters for the queuosine (Q) micronutrient and investigate the role of orphan pyridoxal phosphate (PLP)...
- This $378,715 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is supporting the development of novel aptamer-based biosensing probes for high-resolution chemical imaging of multiple analytes at the single-cell level. The Florida State University (FSU) Lazenby Lab, the awardee, is leveraging electrochemical techniques and aptamer-based sensing platforms to expand the scope of molecules...
- This federal Project Grant award of $359,490.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award funds the development of a suite of deep learning methods for "Single-Cell Genetics," which aims to integrate cutting-edge single-cell genomic data into genetic analysis to address challenges in disease genetics, including variant interpretation, gene discovery, cell...
- This $616,401 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research on enzyme recruitment and metabolic plasticity. The objective is to use biochemistry, evolution experiments, and -omics methods to investigate how cellular features impact enzyme recruitment, which is a key process enabling the evolution of new metabolic pathways. The research will leverage three...
- The Research Foundation for the State University of New York received a $108,512 Project Grant from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) to develop novel immune-modulating itaconate-loaded telodendrimer nanoparticles to target both hyperinflammation and pyroptosis in sepsis. The project aims to address the current gap in therapies that can directly mitigate excessive cytokine production and immune cell pyroptosis,...
This federal Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) provides $2,110,625.00 to the University of Florida to investigate the regulation of selenium metabolism and cellular response to low selenium levels. The 4-year project aims to develop a low selenium cell system that mimics selenium deficiency, and use this model to address two key questions: 1) how regulation of selenium impacts cell viability, and 2) how cells respond to low selenium. The research seeks to advance the understanding of selenium function and the mechanisms by which cells adapt to selenium stress, with potential implications for diseases associated with selenium deficiency. The award commenced on September 1, 2025 and is scheduled for completion on August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.1m | 8/1/25 |