Project Grant R35GM159985
- This Project Grant award for $919,914 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research by the Magee-Womens Research Institute and Foundation in Pittsburgh, Pennsylvania to investigate the regulation of meiotic crossover formation across eukaryotic organisms. The research aims to elucidate the interactions and regulation of the core machinery involved in the formation...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $225,852 Project Grant to The Leland Stanford Junior University to investigate the mechanisms that promote reliable formation of meiotic crossovers, which are essential for orderly chromosome segregation and genome inheritance. The research will focus on the COSA-2 protein, a critical component of the crossover machinery, and use innovative...
- This federal Project Grant award of $380,070.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project titled "ACTIVE CHROMOSOME MOVEMENT IN MEIOTIC PAIRING" at the University of California, San Francisco (UCSF). The project aims to investigate the cellular mechanism of meiotic pairing, testing hypotheses regarding the role of telomere-led active motion and nuclear...
- This Project Grant award of $160,613 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to better understand chromosome-specific mechanisms that ensure accurate meiotic chromosome segregation in Drosophila melanogaster. The long-term goal is to elucidate how chromosomes are identified as unique by the meiotic machinery and how the positioning of double-strand breaks and crossovers is...
- This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the mechanisms and factors that promote aberrant DNA repair during meiosis, leading to the formation of de novo structural variants. The $380,495 award, with a project period from February 1, 2025 to January 31, 2030, will be performed by the Regents of the University of Michigan. The...
- This Project Grant award of $147,486.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to reconstitute the synaptonemal complex (SC) of the nematode Caenorhabditis elegans in vitro using a bacterial protein expression system. The award recipient, The Johns Hopkins University, aims to use the purified SC components to study the molecular architecture and assembly mechanisms of this...
- This federal Project Grant award of $188,627, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), funds the development of tools to measure post-translational modification enzyme activity, with a focus on kinases. The project aims to (1) build understanding of kinase-substrate interactions using techniques like in vitro phosphoproteomics, novel substrate design, and computational methods, and (2) develop...
- This Project Grant award of $434,679 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research on nuclear envelope dynamics and meiotic quality control mechanisms in the nematode Caenorhabditis elegans. The principal investigator at Lehigh University aims to elucidate how the nuclear envelope and mechanosensitive ion channels like PIEZO transduce signals during meiosis to promote apoptosis when...
- This $516,608 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand the mechanisms and regulation of DNA recombination in budding and fission yeast. The key research focus areas are: 1) studying DNA end resection, the critical first step in homologous recombination, within heterochromatin regions, 2) investigating how lagging strand synthesis proceeds during...
- The University of New Mexico received a $335,712 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award will support the development of high-resolution single-molecule imaging techniques to study protein interactions and organizations in cells. Specifically, the project aims to: 1) Develop a two-color single-particle tracking microscope to study the dimerization of epidermal growth...
This federal Project Grant award of $404,058.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project focused on investigating the mechanisms that regulate the formation of crossovers on meiotic chromosomes. The research aims to use single-molecule imaging techniques to understand how the dynamics of proteins that control crossover formation create coordinated patterns along chromosomes. Key objectives include evaluating protein diffusion and binding kinetics at potential crossover sites, and using computational modeling to elucidate the emergent properties that govern crossover distribution. The award was granted to the Regents of the University of Minnesota, a prominent research institution, with a project period from September 1, 2025 to June 30, 2030. This work contributes to the NIGMS program's broader goal of advancing fundamental scientific understanding to support progress in disease diagnosis, treatment, and prevention.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $404.1k | 8/18/25 |