Project Grant R35GM159731
- The University of Pittsburgh received a $275,303 Project Grant award from the National Institute of General Medical Sciences (NIGMS), part of the Biomedical Research and Research Training program (CFDA 93.859), to develop predictive stochastic descriptions of microbial proliferation across the molecular, cellular, and population scales. The goal is to understand the effects of molecular and cell division noise on microbial cell size control and population dynamics, particularly in clinically...
- This $452,250 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at the University of Pittsburgh to investigate the role of nuclear speckles in coordinating protein quality control mechanisms. The overarching goal is to elucidate how nuclear speckles, traditionally viewed as facilitating mRNA processing and gene regulation, function as sensors of proteostatic stress and...
- The University of Pittsburgh received a four-year, $855,989 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences under the Biological Sciences federal grant program (CFDA 47.074). The grant will fund collaborative research between the University of Pittsburgh and other institutions to tackle functional protein states at atomic detail by integrating weighted ensemble simulations with magnetic resonance restraints. Over the period from July 2021 to June...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $410,000 in funding to the University of Chicago to conduct research on bacterial secretion systems using cryo-electron tomography. The key objectives are to: Investigate the assembly, disassembly, and function of bacterial flagellar motors (type III secretion systems) and type IV secretion systems, which are involved in...
- The federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is providing $376,902 to the University of Pittsburgh to conduct research on the "Mechanisms of Alpha-Arrestin-Mediated Protein Trafficking." The research aims to gain a deeper, mechanistic understanding of how alpha-arrestins, a class of protein trafficking adaptors, regulate cellular homeostasis by controlling...
- This federal Project Grant award of $556,510 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program focused on understanding the molecular mechanisms and evolution of the rhoptry secretion system in unicellular eukaryotes within the Alveolata superphylum, including apicomplexan parasites and non-pathogenic ciliates. The research aims to: 1) determine the conserved basic architecture...
- The University of Pittsburgh received a Project Grant award of $397,500.00 on September 4, 2025 from the National Institutes of Health (NIH) under the Biomedical Research and Research Training program (CFDA 93.859) to study the evolution and adaptation of Staphylococcus aureus to nutrient stress. The research aims to understand how S. aureus adapts and evolves in response to the nutrient stress imposed by the host environment during infection. The long-term vision is to use this knowledge to...
- This federal Project Grant award of $437,250.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will fund a 5-year research project at the University of Pittsburgh focused on advanced computational approaches for integrating single-cell multi-omics data. The key objectives of this project are to: 1) Develop novel integration methods for combining single-cell RNA-seq, ATAC-seq, and cytometry data to...
- The University of Pennsylvania was awarded a $443,806 Project Grant by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports fundamental scientific research investigating the collective impacts and regulatory mechanisms of multiple enzyme-mediated modifications across distinct RNA species, particularly in the areas of mRNA, tRNA, and rRNA. The research aims to uncover the extent of crosstalk in...
- The federal Project Grant award of $186,354 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is being used to conduct research on the roles of protein glycosylation in prokaryotes. The project aims to perform quantitative glycoproteomic analyses of the opportunistic bacterial pathogen Pseudomonas aeruginosa during different stages of biofilm formation and in response to antibiotics. Additionally, the...
The University of Pittsburgh is the awardee for a $401,939.00 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant, awarded on August 8, 2025, supports a 5-year research program focused on understanding post-translocation protein secretion mechanisms in gram-positive bacteria. The research aims to identify and characterize secretion chaperone-client repertoires, critical chaperone domains, and the molecular mechanisms governing chaperone-client interactions and regulation. By defining paradigms of gram-positive secretion chaperone-client activation and regulation, the project seeks to provide novel insights into the core biology of these organisms and their interactions with the environment.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $401.9k | 8/7/25 |