Project Grant R35GM158262
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $396,854 to develop innovative nanopore tweezer tools for analyzing the structural dynamics and conformational states of disease-associated kinases. The research aims to track kinase movements in real-time at a 100-microsecond resolution, generating comprehensive energetic maps of kinase behavior during substrate...
- This federal Project Grant award of $387,500.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to determine the molecular mechanisms that regulate the activity of protein kinases. The research will use the Hippo pathway, which controls decisions of cell fate and number, as a model system to investigate different mechanisms that modulate the activity of protein kinases. The goal is to accelerate the...
- This $224,088 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to develop high-throughput microfluidic technology for studying enzyme function using non-canonical amino acids. The project will leverage the High-Throughput Microfluidic Enzyme Kinetics (HT-MEK) platform developed at Stanford University to enable the parallel expression, purification, and quantitative assay...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of engineered enzymes that can be activated to perform targeted modifications of cellular proteins. The $1,602,000 award to the Dana-Farber Cancer Institute, Inc. (DFCI) will fund research to design and apply novel autoinhibited enzymes that can toggle between inactive and active conformations in response...
- The federal Project Grant award of $420,066.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund research to systematically characterize how regulatory networks control secondary metabolism in microbes. The project aims to use genome-wide screens and multi-omics approaches to predict and access the unexplored biosynthetic potential of microbes, with the goal of accelerating the discovery,...
- This federal Project Grant award of $645,712 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of chemical biology tools to provide critical insights into protein post-translational modification (PTM) networks, with a focus on glycation and ubiquitination, in living cells. The research aims to unlock previously unattainable information to address questions about the role of these...
- This federal Project Grant award of $452,192.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of pan- and phospho-specific nanobodies for investigating MAPK and PP2A signaling. The award to Vanderbilt University, effective June 1, 2025, aims to further the fundamental scientific understanding of protein phosphorylation, an essential cellular process, through the creation of...
- This Project Grant award of $1,792,800.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a nuclear alpha-ketoglutarate (AKG) biosensor system to study the metabolic control of the epigenome. The project, awarded to the University of Texas Southwestern Medical Center, will create a new biomedical research tool to quantify changes in nuclear AKG levels with high...
- This federal Project Grant award of $404,058.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project focused on investigating the mechanisms that regulate the formation of crossovers on meiotic chromosomes. The research aims to use single-molecule imaging techniques to understand how the dynamics of proteins that control crossover formation create coordinated patterns along...
- The University of New Mexico received a $335,712 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award will support the development of high-resolution single-molecule imaging techniques to study protein interactions and organizations in cells. Specifically, the project aims to: 1) Develop a two-color single-particle tracking microscope to study the dimerization of epidermal growth...
This federal Project Grant award of $188,627, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), funds the development of tools to measure post-translational modification enzyme activity, with a focus on kinases. The project aims to (1) build understanding of kinase-substrate interactions using techniques like in vitro phosphoproteomics, novel substrate design, and computational methods, and (2) develop diverse assay read-out detection methods for applications ranging from drug screening to basic research on enzyme function and substrate interactions in cells. The award is held by the Regents of the University of Minnesota, Office of Sponsored Projects Administration, and covers the period from Sep 1, 2025 to Aug 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $188.6k | 8/15/25 |