This $1,050,000 Project Grant, awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074), aims to study how extreme environments shape the regulatory networks of transcription in microbes called archaea. The research project, conducted by Duke University, will focus on haloarchaea - a group of archaea that thrive in extremely salty environments. The project's key objectives are to: (1) use genetics, genomics, and statistical modeling to compare the architecture...
The National Institute of General Medical Sciences (NIGMS) is providing a 5-year, $370,976 project grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Kansas Center for Research Inc. to identify genetic variants affecting gene regulation that underlie complex trait variation and fitness in natural populations. The research aims to integrate studies of tissue-specific gene regulation, population genomic surveys, and new sequencing/computational...
The University of Chicago was awarded a $401,296 Project Grant under the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) to elucidate the role that 3D genome folding plays in shaping transcriptional regulatory strategies in animals. The project aims to generate 3D genome maps in outgroups to the vertebrates and to the bilateria, functionally assay the role of chromatin-interacting proteins isolated from these lineages, and...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA 93.859 Biomedical Research and Research Training Program, provides $396,510.00 to Brandeis University to conduct research on how archaeal microbes respond to mechanical stresses and environmental changes that mimic the human microbiome. The research aims to advance the mechanistic understanding of how microbiome complexity influences human physiology. The award supports a 5-year project (1/1/2025...
The Project Grant award R35GM149520 in the amount of $775,170 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research to decode the regulatory mechanisms within the human genome. The project aims to better understand how transcription factors and other regulatory DNA features cooperatively control gene expression patterns during development and in response to various stimuli. Using advanced...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA 93.859 Biomedical Research and Research Training program, provides $1,158,381 to Purdue University to conduct research on the genetic and evolutionary mechanisms underlying the origins of new molecular functions. The 5-year project, running from July 1, 2024 to April 30, 2029, aims to improve the understanding of how gene regulation functions and evolves in order to better predict the...
This $387,662 federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research at Duke University to elucidate the molecular mechanisms of cellular mechanosensitivity. The project aims to develop biosensors to study how protein phosphorylation affects the mechanical state of linker proteins, identify key mediators of mechanosensitivity, and evaluate the role of these...
This $1,507,500.00 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support Yale University's research project to "Trace the Evolutionary History of Human Adaptive Traits Through Ancient DNA." The project aims to investigate the origin and evolution of genetic adaptations in modern humans by analyzing ancient human DNA extracted from archaeological sediment samples in...
The National Institute of General Medical Sciences (NIGMS) awarded a $451,910 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Duke University on July 17, 2024. The purpose of this grant is to characterize the mechanisms by which retrotransposons, a class of highly abundant genomic elements, hijack the host's DNA repair pathways to synthesize circular DNA that can impact host biology. Specifically, the research aims to: 1) determine how the alternative end-joining...
The National Institute of General Medical Sciences (NIGMS) awarded a $451,802 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to The Pennsylvania State University (Penn State) to conduct a structural study of the direct associations between cellular RNA polymerase and regulatory factors during the transcription cycle. The funding will support groundbreaking cryo-electron microscopy and single-molecule investigations to examine the heterogeneity and dynamics of RNA...