Project Grant R35GM158092
- This $659,122 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), to the University of Notre Dame DU Lac. The grant supports research to understand how the ESX-1 secretion system in pathogenic mycobacteria, such as Mycobacterium tuberculosis, allows these bacteria to lyse phagosomes and infect host cells in response to varying pH conditions. The goal is to gain...
- The University of Notre Dame received a $491,300 Project Grant award from the National Science Foundation Division of Chemistry on September 1, 2021 to support research titled "SELF-IMMOLATIVE BOLAAMPHIPHILES FOR SIGNAL TRANSDUCTION ACROSS BILAYER MEMBRANES." The award will fund research through August 31, 2024 under the NSF's Mathematical and Physical Sciences program (CFDA 47.049), which aims to promote progress in these scientific fields and strengthen the national scientific...
- The University of Notre Dame DU Lac's Notre Dame Research Division, doing business as the Office of Research, received a $471,006.00 Project Grant award from the Defense Health Agency under the Military Medical Research and Development (CFDA 12.420) program. The 3-year grant, awarded on September 15, 2023, supports a bench-bedside-bidirectional investigation of a new combinatorial immunotherapy strategy to treat platinum-resistant penile cancer. As a leading research university, the University...
- This federal Project Grant award of $250,000 was provided by the Defense Health Agency under the Military Medical Research and Development (CFDA 12.420) program. The funding will support research at the University of Notre Dame DU Lac aimed at "TARGETING NEURAL STEM CELL QUIESCENCE TO PROMOTE REMYELINATION", with a project period from September 1, 2024 to August 31, 2026. The research focuses on developing innovative approaches to address critical medical challenges facing military...
- The University of Notre Dame DU Lac's Notre Dame Research division has been awarded a $343,891 Project Grant from the U.S. Army under the Basic Scientific Research (CFDA 12.431) program. The grant, titled "ENHANCED FUNCTIONALITY OF THE REDI-NET PIPELINE TO STRENGTHEN FORCE HEALTH PROTECTION INTELLIGENCE", will fund research and development to improve the REDI-NET pipeline, which supports force health protection intelligence. This work aims to advance capabilities in areas such as...
- This Project Grant award, totaling $387,857.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a research project titled "A Molecular Recognition Guidebook for Targeting Protein Loops with Covalent Ligands" at the University of Notre Dame DU Lac. The project aims to elucidate the structural and biophysical principles governing the interactions between small molecule...
- This federal Project Grant award for $543,750.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), will support research to determine the structural basis by which a C-terminal processing protease activates cell surface signaling for iron import in gram-negative bacteria. The research, to be conducted at North Dakota State University, aims to better understand essential cellular processes in...
- The University of Notre Dame received a $460,000 project grant award from the National Science Foundation Division of Chemistry on July 1, 2021 for research concluding on June 30, 2024. The award is part of the NSF's Mathematical and Physical Sciences program (CFDA 47.049), which aims to advance scientific knowledge and understanding of major issues. Specifically, the funding will support the University's "BACKBONE N-HETEROATOM PROTEIN ORTHOTICS" research project. While further details...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $705,896 to the University of Notre Dame to investigate emerging artemisinin partner drug resistance in Eastern Africa. The key objectives are to: Conduct a detailed analysis of in vitro phenotypes and genome variation in P. falciparum isolates from African patients who failed artemether-lumefantrine (AL) treatment, creating a...
- The University of Notre Dame DU Lac was awarded a $1,604,627.00 Project Grant from the Department of the Navy's Office of Naval Research (ONR) under the Basic and Applied Scientific Research program (CFDA 12.300) to support masters and STEM programs in hypersonic systems. The award began on March 1, 2025 and is scheduled for completion by February 28, 2028. This grant supports fundamental and applied research at the university across a range of scientific and technological domains critical to...
The University of Notre Dame DU Lac was awarded a $414,725 Project Grant from the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) to conduct research on targeting gram-negative bacteria for antibacterial strategies. The project, which runs from September 1, 2025 to July 31, 2030, focuses on studying the cytoplasmic pathway for recycling of muropeptides, which are fragments of the bacterial cell wall, and the mechanistic nexus between cell-wall recycling and resistance to beta-lactam antibiotics. The research aims to develop a better understanding of the complex biosynthetic and recycling processes of the bacterial cell wall and its regulation, with the goal of identifying potential targets for novel antibacterial strategies against gram-negative bacteria like Pseudomonas aeruginosa.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $414.7k | 8/12/25 |