Project Grant R35GM158065
- This $453,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to define the molecular mechanisms and cellular dynamics required to assemble a functional stem cell niche during embryonic development. The research, conducted at East Carolina University, aims to elucidate the signaling pathways, transcriptional regulators, and cytoskeletal processes that guide the migration and...
- The National Institute of General Medical Sciences (NIGMS) awarded a $180,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Kennesaw State University (KSU) to measure the functional requirement of the ecdysone receptor (ECR) transcriptional regulation during Drosophila development. The primary objectives are to: (1) determine if ECR activation is an important mode of transcriptional regulation for ECR signaling during development, and (2) assess how...
- This Project Grant award of $287,800 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research by the Whitehead Institute for Biomedical Research to comprehensively characterize how adult stem cell systems balance regenerative plasticity with the maintenance of discrete cell behaviors. The project aims to determine how combinatorial signaling from the stem cell niche yields distinct cellular states,...
- This $423,890 Project Grant was awarded on September 1, 2025 by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859). The grant is being used to support fundamental scientific research and advanced training focused on understanding the mechanisms underlying the survival and uncontrolled proliferation of stem cells with DNA damage, and the influence of surrounding tissues on stem cell behavior during tissue...
- This federal Project Grant award, valued at $2,043,430.00 and provided by the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 - Biomedical Research and Research Training, supports research by Syracuse University to develop stem cell-based modeling systems that can closely replicate early human embryonic development, with a focus on elucidating the fundamental mechanisms governing the specification, maturation, and migration of human primordial germ cells (the...
- This $162,874 Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to The Trustees of Princeton University. The goal of this research project is to quantify protein dynamics and post-transcriptional regulation within the ectoderm germ layer of Drosophila (fruit fly) embryos. The researchers will use genetically modified Drosophila embryos expressing uniform morphogens to analyze...
- The National Institute of General Medical Sciences (NIGMS) awarded a $248,975 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Yale University on August 28, 2025. The project, titled "Stress Response Signaling as a Metabolic Sensor in Reproduction," aims to examine how nutrient sensing alters reproductive capacity via the integrated stress response (ISR) signaling pathway and steroid hormones in the Drosophila model organism. The research...
- This federal Project Grant award, valued at $428,202.00 and funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project to elucidate the systems-level mechanisms that generate robustness in organ size and shape. The principal investigator, based at Cornell University, will leverage advanced live imaging, genetic engineering, image processing, and computational modeling to investigate...
- This federal Project Grant award of $393,093, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project titled "Uncovering Spatio-Temporal, Mechano-Transcriptomic Signatures of Development". The principal investigator is Bianca Dumitrascu. The goal of this 5-year project is to understand the interplay between gene expression, cell morphology, and tissue-level mechanics in...
- This federal Project Grant award of $565,826.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research conducted by Duke University to investigate how animals, using the C. elegans model organism, maintain developmental homeostasis and respond to fluctuations in nutrient availability. The research focuses on elucidating the role of key regulatory pathways, such as insulin/IGF signaling and...
This federal Project Grant award for $473,955.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program at East Carolina University focused on elucidating the molecular mechanisms by which the steroid hormone ecdysone regulates germline stem cell homeostasis in the Drosophila ovary. The research aims to characterize how ecdysone receptor signaling in germline stem cells integrates with intrinsic cell cycle regulators and local signals from neighboring somatic cells to maintain stem cell function. The project will employ genetic manipulation, quantitative imaging, and single-cell transcriptomics to define the cell-autonomous mechanisms by which ecdysone receptor controls asymmetric stem cell division. This research is expected to advance fundamental understanding of how hormonal signals coordinate with local cues to govern stem cell behavior, with potential implications for stem cell-based regenerative therapies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $474.0k | 7/31/25 |