This $508,315 Project Grant awarded on January 1, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at the University of California, San Diego (UCSD) to investigate the molecular mechanisms driving development during the period of transcriptional silence from oocyte to embryo in mammals.
The overarching goal of this multi-year project is to uncover the post-transcriptional regulatory mechanisms, such as mRNA polyadenylation, that enable gene expression and developmental progression in the absence of new transcription during the oocyte-to-embryo transition. The research aims to characterize the drivers of global transcriptional silencing in the oocyte, the dynamics of poly(A) tail regulation and translation, and the maternal factors mediating the reprogramming to totipotency. This work will advance the understanding of this critical developmental window and has the potential to improve diagnosis and treatment of infertility.
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