The National Institute of General Medical Sciences (NIGMS) awarded a $647,301 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the Massachusetts Institute of Technology (MIT) to conduct research on the mechanisms of iron-sulfur enzymes. The 5-year project, running from February 1, 2025 to January 31, 2030, will focus on two key objectives:
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Advancing the synthetic modeling chemistry of iron-sulfur proteins to elucidate the structures and electronic properties of enzymatic intermediates. This will involve synthesizing iron-sulfur clusters that mimic those found in natural systems and characterizing their spectroscopic data for comparison to biological samples.
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Developing methods for site-selective incorporation of the 57Fe isotope into biological iron-sulfur clusters. This will enhance the resolution and interpretability of Mössbauer and ENDOR spectroscopic data, providing deeper insight into the chemical bonding and reactivity of these important enzyme cofactors.
The project aims to shed light on the mechanisms of iron-sulfur enzymes relevant to human health and disease, which could support the development of new inhibitors and treatments.
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