Project Grant R35GM156786
- This Project Grant award for $185,000.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a research project at the University of North Florida to examine the role of J-domain protein interactions with the molecular chaperone HSP70 and their impact on protein folding and misfolding processes. The research aims to further the understanding of how J-domain protein/HSP70 systems...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $2,282,500 to the University of Southern California (USC) to deepen the understanding of the molecules and mechanisms that drive protein aggregation. The research aims to explore the biological implications of disaggregases, which are enzymes that can both catalyze and inhibit protein aggregation, and how they may...
- This $153,488 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate the mechanisms by which the HSP70 molecular chaperone system interacts with the AAA+ disaggregase HSP104 to target and solubilize toxic amyloid aggregates. The research aims to use biochemical and cryo-EM structural approaches to define the precise interaction between HSP70 and HSP104, and how this...
- This Project Grant award, valued at $379,394.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a research project investigating the mechanisms by which human cells detect and respond to oxidative stress, with a focus on understanding the dose-dependent activation of key stress response proteins. The research aims to uncover how dynamic stress response pathways influence cell...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $444,125.00 to the Rector & Visitors of the University of Virginia (UVA) to conduct research on the molecular mechanisms of protein sorting and localization to organelles. The research aims to uncover how nascent polypeptide chains are processed and folded by chaperones during transport across the endoplasmic...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $148,568 to the University of Massachusetts to investigate the interactions of the enzyme UDP-glucose:glycoprotein glucosyltransferase (UGGT) with its substrates and co-chaperone. The goal is to utilize cellular and biophysical experiments to gain structural insights into the concerted action of UGGT and its co-chaperone protein Sep15...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $425,803 to The University of Mississippi to elucidate the structural attributes and functions of the cytosolic heat shock protein 70 (HSP70) and its role in maintaining cellular integrity and stress response. The research aims to investigate HSP70's lectin-like capacity to bind O-GlcNAcylated proteins, its ability to bind...
- This federal Project Grant award of $584,420 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the "Spatiotemporal Mapping and Engineering in the Dark Proteome" research project at the Albert Einstein College of Medicine. The research aims to investigate how protein motions associated with intrinsic disorder contribute to specific biological functions, utilizing methods such as NMR,...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop new chemical strategies for controlling the conformation of bioactive peptides and proteins. The $385,671 award, effective from September 1, 2025 to August 31, 2030, aims to synthesize and evaluate novel amino acid analogs that can influence the secondary structures of peptides and proteins, with the goal...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund a $540,000 research project at Northwestern University to measure the global folding stability and folding energy landscapes for 3 million protein sequences. The project aims to create a large dataset quantifying these properties, which have historically been challenging to investigate at scale. This data will empower...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $272,596 to the University of Arizona to conduct research on how chaperone proteins assist in protein folding and prevent toxic protein aggregation. The research aims to address four key questions: 1) how ATP induces conformational changes in the subunits of the Hsp60 chaperone, 2) how substrates interact with chaperones, 3) the role of the Hsp10 chaperone in assisting Hsp60, and 4) the mechanisms by which chaperones prevent the formation of toxic protein aggregates. This foundational research has potential implications for understanding and treating diseases associated with protein misfolding, such as Alzheimer's, Parkinson's, and Huntington's diseases. The award period runs from August 1, 2025 to July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $272.6k | 7/28/25 |