Project Grant R35GM156452

Award Date 5/1/25
Completion Date 2/28/30
Dollars Obligated $502K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Massachusetts, USA
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  1. Dissect the metal-dependent activities of viral proteases from SARS-CoV-2, porcine reproductive and respiratory syndrome virus, hepatitis E virus, and enterovirus 71, to better understand their role in manipulating host immune response.

  2. Elucidate the role of Fe and Mn in activation and catalysis of human SAMHD1 dNTPase, as well as map the functional repertoire of newly identified SAMHD1 orthologs across diverse eukaryotes and viruses.

This research aims to provide molecular-level insights into how metal-dependent enzymes regulate critical cellular processes and virus-host interactions, with potential implications for disease diagnosis, treatment, and prevention.

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